FMP micropatterning 4Dcell微模式技術(shù)支持2D單元格幾何形狀控制。在玻璃底部設(shè)置一組圖案以接收單元格。使用一種抗粘劑和一些ECM蛋白，如纖維連接蛋白或膠原蛋白，細(xì)胞可以附著在微模式施加的形狀。單元格將接受這個(gè)新環(huán)境的幾何形狀。細(xì)胞標(biāo)準(zhǔn)化:器官生理學(xué)活器官細(xì)胞的規(guī)律性生理與其空間和機(jī)械組織密切相關(guān)。FMPsTM提供了簡(jiǎn)單和具有代表性的模型，突出了特定機(jī)構(gòu)的讀出。例如，F(xiàn)MPsTM微模式誘導(dǎo)心肌細(xì)胞紋狀，導(dǎo)致心肌細(xì)胞的標(biāo)準(zhǔn)化搏動(dòng)特性和內(nèi)部組織。

4Dcell微圖案多孔板具有組織良好的培養(yǎng)基質(zhì)，可實(shí)現(xiàn)細(xì)胞的歸一化。細(xì)胞均勻分布在膠粘劑上，具有可控的幾何形狀，可使檢測(cè)標(biāo)準(zhǔn)化。FMP micropatterning

4Dcell micropatterned multi-well plates hold a perfectly organized culture substrate aiming for cell normalization. Evenly distributed on adhesive patterns, cells have a controlled geometry allowing a standardization of the assays.

The 4Dcell micropatterning technology enables a 2D cell geometry control. A set of patterns is arranged on a glass bottom to receive cells. Using an anti adhesive agent and some ECM proteins such as fibronectin or collagen, cells can adhere to the shape imposed by the micropattern. Cells are going to embrace the geometry of this new environment.

CELL STANDARDIZATION: ORGAN PHYSIOLOGY

The regular physiology of cells in living organs is closely linked with its spatial and mechanical organization.

FMPsTM offer simple and representative models highlighting organ specific read-outs. For instance, FMPsTM Micropatterns induce striation of cardiomyocyte leading to standardized beating properties and internal organization.