化工儀器網(wǎng)>產(chǎn)品展廳>生命科學(xué)儀器>神經(jīng)生物學(xué)儀器>細(xì)胞/組織支持系統(tǒng)>Mouse GM-CSF protein 重組小鼠粒細(xì)胞-巨噬細(xì)胞集落刺激因子（GM-CSF）2
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細(xì)胞代謝、細(xì)胞凋亡、細(xì)胞增殖、細(xì)胞氧化應(yīng)激、細(xì)胞損傷與修復(fù)、細(xì)胞活力、遷移、侵襲、趨化、干細(xì)胞
| 產(chǎn)品英文名稱 | Mouse GM-CSF protein |
| 產(chǎn)品中文名稱 | 重組小鼠粒細(xì)胞-巨噬細(xì)胞集落刺激因子（GM-CSF） |
| 別名 | CSF; CSF2; CSF-2; GMCSF; GM-CSF;colony stimulating factor 2 (granulocyte-macrophage); granulocyte-macrophage colony-stimulating factor; Colony-stimulating factor; GMCSF, granulocyte-macrophage colony stimulating factor; molgramostin; Sargramostim, MGC131935; MGC138897; Molgramostim; |
| 分子 | GM-CSF |
| 標(biāo)簽 | 無標(biāo)簽 |
| 種屬 | 小鼠 |
| 序列 | Amino acid sequence derived from Mouse GM-CSF protein isoform (P01587，Met1-Lys141) was expressed. |
| 活性 | 通過其在FDC-P1細(xì)胞中誘導(dǎo)增殖的能力在0.009-2.5 ng/mL的線性范圍內(nèi)測(cè)量。 |
| 蛋白長度 | 重組小鼠GM-CSF蛋白由128個(gè)氨基酸組成，預(yù)測(cè)分子量為14.6 kDa。 在還原條件下，SDS-PAGE中小鼠GM-CSF蛋白的表觀分子量約為15-25 kDa。 |
| 純度 | ≥ 90 % ，使用SDS-PAGE檢測(cè) |
| 特點(diǎn)&優(yōu)勢(shì) | 采用 LAL 法檢測(cè)，每 1 μg 蛋白質(zhì)中的 EU 含量小于 1.0。 |
| 產(chǎn)品形式 | 凍干粉，凍干緩沖液為無菌的 PBS，pH 7.4。 |
| 基因ID | 12981 |
| 蛋白序列鏈接 | /uniprot/P01587 |
| 使用中注意事項(xiàng) | 開蓋使用前，請(qǐng)先離心。本產(chǎn)品為凍干粉，推薦用該產(chǎn)品配套的Reconstitution Buffer進(jìn)行復(fù)溶，且濃度不低于100 µg/mL?？蛻艨筛鶕?jù)后續(xù)的實(shí)驗(yàn)需求，進(jìn)行進(jìn)一步的稀釋。 |
| 保存建議 | 本產(chǎn)品為凍干粉形式，建議：將凍干粉的重組小鼠粒細(xì)胞-巨噬細(xì)胞集落刺激因子（GM-CSF）產(chǎn)品保存于-20℃以下的干燥環(huán)境中。本產(chǎn)品溶解之后，可在4℃保存2-7天，長期使用請(qǐng)置于-20℃以下。為長期保存，推薦添加載體蛋白（0.1% HSA或者BSA），并酌情分裝保存，避免反復(fù)凍融。 |
| 運(yùn)輸條件 | 常溫運(yùn)輸 |
| 警告 | 本文列出的產(chǎn)品僅供研究使用，不適用于人類或臨床診斷。我們產(chǎn)品所推薦應(yīng)用，不是建議使用我們的產(chǎn)品去違反任何或許可證。對(duì)于使用本產(chǎn)品可能發(fā)生的侵權(quán)或其他違規(guī)行為，我們不承擔(dān)任何責(zé)任。 |
| 背景 | The granulocyte-macrophage colony-stimulating factor (GM-CSF) is an important hematopoietic growth factor and immune modulator. GM-CSF also has profound effects on the functional activities of various circulating leukocytes. It is produced by a variety of cell types including T cells, macrophages, endothelial cells and fibroblasts upon receiving immune stimuli. Although GM-CSF is produced locally, it can act in a paracrine fashion to recruit circulating neutrophils, monocytes and lymphocytes to enhance their functions in host defense. GM-CSF was initially classified as a hematopoietic growth factor. However, unlike its close relatives macrophage CSF (M-CSF) and granulocyte CSF (G-CSF), the majority of myeloid cells do not require GM-CSF for steady-state myelopoiesis. Instead, in inflammation, GM-CSF serves as a communication conduit between tissue-invading lymphocytes and myeloid cells. Even though lymphocytes are in all likelihood the instigators of chronic inflammatory disease, GM-CSF-activated phagocytes are well equipped to cause tissue damage. |
Fig.SDS-PAGE analysis of Mouse GM-CSF protei.
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