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而Davies和同事已經(jīng)開始更直接地檢驗(yàn)他們的理論,以應(yīng)對(duì)質(zhì)疑。Davies 解釋稱,“我們理論的關(guān)鍵是考慮癌癥基因的年齡。”返祖模型顯示,在癌癥起始階段,細(xì)胞能恢復(fù)成更原始的模型,而且進(jìn)化出的功能會(huì)被關(guān)閉。該研究小組因此預(yù)測(cè),在癌癥發(fā)展過(guò)程中,進(jìn)化的基因?qū)适Чδ?,反之古老基因?huì)被激活。
為了檢測(cè)該假設(shè)是否正確,Davies研究小組交叉引用了當(dāng)前的癌癥基因組圖譜數(shù)據(jù)和各種分類基因的數(shù)據(jù)庫(kù)。這些數(shù)據(jù)能幫助生物學(xué)家追溯基因的年齡?;蚰挲g和癌癥間的任何相關(guān)性,將能支持返祖模型。“之前從未將這些數(shù)據(jù)集合起來(lái),但數(shù)據(jù)挖掘工作十分重要,這也是我們目前在做的工作。”Davies說(shuō)。
澳大利亞阿德萊德大學(xué)腫瘤外科醫(yī)生、免疫治療師Brendon Coventry看到了物理學(xué)家和腫瘤學(xué)家研究的價(jià)值,他們拼湊了現(xiàn)存的醫(yī)學(xué)證據(jù),試著理解癌癥的起源。“投入到生物學(xué)和醫(yī)學(xué)中的龐大資金和智力資源都未能在正常抗癌戰(zhàn)爭(zhēng)中取得重大突破,或許是時(shí)候采取新視角了。”Coventry說(shuō),“一位宇宙學(xué)家能將細(xì)胞視為‘內(nèi)部宇宙’,并利用新方法對(duì)其進(jìn)行探索。”
And Davies and colleagues have begun to test their theories more directly in response to questions. Davies explains that "the key to our theory is to think about the age of the cancer genes." The regression model shows that in the initial stages of cancer, cells can recover to a more primitive model and the newly evolved functions are shut down. The team therefore predicted that in the process of cancer development, the latest evolution of genes will lose its function, whereas the ancient genes will be activated.
To test whether this hypothesis is correct, the Davies team cross-references current cancer genome mapping data and databases of various taxa. These data can help biologists trace the gene's age. Any correlation between gene age and cancer will support regression models. "I've never put together these data before, but data mining is so important and that's what we're doing right now," says Davies.
Brendon Coventry, a tumor surgeon and immunotherapist at the University of Adelaide in Australia, sees the value of research done by physicists and oncologists who put together existing medical evidence and try to understand the origins of cancer. "It is perhaps time to take a fresh perspective for both the huge capital and inlectual resources devoted to biology and medicine to fail to make major breakthroughs in the normal war on cancer," said Coventry. "A cosmologist can think of cells as 'Internal universe' and explore it with new methods. "
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