crosslinkers 功能化蛋白交聯(lián)劑列表- SMPH/DSS

crosslinkers 功能化蛋白交聯(lián)劑列表- SMPH/DSS

crosslinkers 功能化蛋白交聯(lián)劑列表- SMPH/DSS

雙功能蛋白交聯(lián)劑和交聯(lián)劑介紹（含結(jié)構(gòu)式和英文介紹）

Protein Biotinylation crosslinkers 功能化蛋白交聯(lián)劑- SMPH/DSS/BS2G

蛋白質(zhì)交聯(lián)劑是一類小分子化合物，具有2個或者多的針對基團(tuán)（-NH2、-COOH、-HS等）的反應(yīng)性末端，可以和2個或者多的分子分別偶聯(lián)，從而使這些分子結(jié)合在一起，終形成共軛蛋白。

Protein crosslinkers are chemical compounds used to covalently bind, or conjugate, biomolecules together. In proteomics, "protein crosslinking" refers to utilizing protein crosslinkers to conjugate peptides or proteins together or to immobilize proteins to a solid support.

Protein crosslinking reagents possess reactive moieties specific to various functional groups (sulfhydryls, amines, carbohydrates, etc.) on proteins, peptides, or other molecular complexes. The atoms separating a crosslinker’s reactive groups, and eventually the conjugated proteins, form the “spacer arm”. A zero-length crosslinker refers to protein crosslinkers that join two molecules without adding additional spacer arm atoms. Homobifunctional crosslinkers have the same reactive group on both ends of the spacer arm (i.e., Amine Reactive-Amine Reactive); while heterobifunctional crosslinkers have different reactive groups on each end of a spacer arm (i.e., Sulfhydryl Reactive-Amine Reactive).

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Zero-Length Crosslinkers零長度交聯(lián)劑：

產(chǎn)品名稱：Sulfo-NHS

產(chǎn)品簡介：N-hydroxysulfosuccinimide (Sulfo-NHS) is used in conjunction with EDC-HCl (EDAC-HCl) to convert carboxyl groups to Sulfo-NHS esters which react amines. Sulfo-NHS is used as a catalyst for EDC-HCl coupling and greatly increases the efficiency of the reaction.

結(jié)構(gòu)式：

分子量: 217.1

CAS #: 106627-54-7

Alternative Name: Hydroxy-2,5-dioxoyrrolidine-3-sulfonate

Homobifunctional Crosslinkers 同端雙功能交聯(lián)劑：

產(chǎn)品名稱：BS3

產(chǎn)品介紹：BS3 crosslinker (Bis[sulfosuccinimidyl] suberate; BS3) is a water soluble homobifunctional pro-tein crosslinker. The 8-atom spacer arm of the BS3 crosslinking reagent is non-cleavable and the molecule is not cell membrane permeable. The BS3 protein crosslinker possesses amino reactive Sulfo-NHS esters on both ends of the molecule and can be used to prepare antibody-protein con-jugates or for crosslinking cell surface proteins.

結(jié)構(gòu)式：

分子量：572 Da

CAS #: 82436-77-9

Spacer Length: 11.4 Å

Alternative Names: Suberic acid bis(3-sulfo-N-hydroxysuccinimide ester); BS3; Sulfo-DSS

產(chǎn)品名稱：BS2G

簡介：BS2G crosslinker (Bis[Sulfosuccinimidyl] glutarate) is a water soluble homobifunctional protein crosslinker. The BS2G protein crosslinker's 5-atom (7.7 angstrom) spacer arm is non-cleavable and the molecule is not cell membrane permeable. The BS2G crosslinking reagent's Sulfo-NHS esters are amino reactive and can be used to label cell surface proteins.

結(jié)構(gòu)式：

Molecular Weight: 530.4

Spacer Length: 7.7 Å

Alternative Names: Glutaric acid bis (3-sulfo-N-hydroxysuccinimide ester); Sulfo-DSG

產(chǎn)品名稱：BSG

簡介：DSG crosslinker (Disuccinimidyl glutarate) is a homobifunctional crosslinking reagent that is membrane permeable. DSG crosslinking takes place through amine-reactive NHS esters at both ends of a 5-atom (7.7 angstrom) spacer arm. DSG must be dissolved in an organic solvent, such as DMSO or DMF, then added to an aqueous crosslinking reaction.

結(jié)構(gòu)式：

Molecular Weight: 326.3

CAS #: 79642-50-5

Spacer Length: 7.7 Å

Alternative Name: Di(N-succinimidyl) glutarate

產(chǎn)品名稱：DSP

簡介：Dithiobis(succinimidyl propionate) (DSP) is a homobifunctional crosslinker that is cell membrane permeable. DSP has amine-reactive N-hydroxysuccimide (NHS) esters at both ends of a cleava-ble, 8-atom (12.0 angstrom) spacer arm. DSP contains a reducible disulfide bond in the spacer arm that make it a good choice for various applications.

結(jié)構(gòu)式：

Molecular Weight: 404.4

CAS #: 57757-57-0

Spacer Length: 12.0 Å

Alternative Names: 3,3′-Dithiodipropionic acid di(N-hydroxysuccinimide ester);

產(chǎn)品名稱：DSS

簡介：DSS crosslinker (Disuccinimidyl suberate) is a homobifunctional crosslinker that is cell membrane permeable. DSS has amine-reactive NHS esters at both ends of an 8-atom (11.4 angstrom) spacer arm. The DSS crosslinking reagent must be dissolved in an or-ganic solvent, such as DMSO or DMF, then added to an aqueous crosslinking reaction.

結(jié)構(gòu)式：

Molecular Weight: 368.4

CAS #: 68528-80-3

Spacer Length: 11.4 Å

Alternative Name: Suberic acid bis(N-hydroxysuccinimide)

產(chǎn)品名稱：DTSSP

簡介：DTSSP crosslinker (3,3´-Dithiobis[sulfosuccinimidylpropionate]) is a homobifunctional protein crosslinker that is cell membrane impermeable. DTSSP crosslinking reagent has primary amine-reactive N-hydroxysulfosuccinimide (Sulfo-NHS) esters at both ends of a cleavable, 8-atom (12.0 angstrom) spacer arm. DTSSP contains a reducible disulfide (thiol) bond in the spacer arm that make it a good choice for various applications.

結(jié)構(gòu)式：

Molecular Weight: 608.5

CAS #: 81069-02-5

Spacer Length: 12.0 Å

產(chǎn)品名稱：EGS

簡介：EGS crosslinker, Ethylene glycolbis(succinimidylsuccinate), is a water insoluble homobifunction-al crosslinker. The 12-atom spacer arm of the EGS crosslinking reagent is cleavable. The EGS spacer arm is cleaved by hydroxylamine at pH 8.5 for 3-6 hours at 37°C. The EGS protein cross-linker possesses amino reactive NHS esters on both ends of the molecule and can be used to label intracellular proteins, since the molecule is cell membrane permeable.

結(jié)構(gòu)式：

Molecular Weight: 456.36

CAS #: 70539-42-3

Spacer Length: 16.1 Å

產(chǎn)品名稱：Sulfo-EGS

簡介：Sulfo-EGS crosslinker, Ethylene glycolbis(sulfosuccinimidylsuccinate), is a water soluble homo-bifunctional crosslinker. The 12-atom spacer arm of Sulfo-EGS crosslinking reagent is cleavable. Sulfo-EGS spacer arm is cleaved by hydroxylamine at pH 8.5 for 3-6 hours at 37°C. The Sulfo-EGS protein crosslinker possesses amino reactive Sulfo-NHS esters on both ends of the molecule and can be used to label cell surface proteins, since the molecule is not cell membrane permeable.

結(jié)構(gòu)式：

Molecular Weight: 660.45

Spacer Length: 16.1 Å

Alternative Names: Ethylene glycol bis (sulfosuccinimidylsuccinate);

產(chǎn)品名稱：DSSeb

簡介：DSSeb (Disuccinimidyl sebacateis membrane permeable. DSSeb crosslinks via amine-reactive NHS esters at both ends of a 10-atom (14.1 Å ) spacer arm and must dissolved in an organic sol-vent, such as DMSO or DMF, then added to an aqueous crosslinking reaction.

結(jié)構(gòu)式：

Molecular Weight: 396.39

CAS # 23024-29-5

Spacer Length: 14.1 Å

Alternative Names: Sebacic acid bis(N-hydroxysuccinimide ester);

Heterobifunctional Crosslinkers異端雙功能交聯(lián)劑：

產(chǎn)品名稱：BMPS

簡介：BMPS is a non-cleavable, water insoluble, heterobifunctional protein crosslinker that is common-ly used to crosslink haptens to carrier proteins and enzymes to antibody. The BMPS crosslinker's spacer arm length of 5.9 angstroms is the shortest of the C3 homolog of aliphatic spacer series (see also EMCS and GMBS). The BMPS crosslinking reagent's NHS ester and maleimide reac-tive groups react with amino and sulfhydryl moites, respectively.

結(jié)構(gòu)式：

Molecular Weight: 266.2

CAS #: 55750-62-4

Spacer Length: 5.9 Å

Alternative Names: N-(beta-Maleimidopropyloxy)succinimide ester

產(chǎn)品名稱：EMCS

簡介：N-(e-Maleimidocaproyloxy)succinimide ester (EMCS) is a non-cleavable, water insoluble, hetero-bifunctional crosslinker that is commonly used to crosslink haptens to carrier proteins and en-zyme to antibody. The EMCS crosslinker spacer arm is longer than GMBS. The EMCS NHS es-ter and maleimide reactive groups react with amino and sulfhydryl moieties, respectively.

結(jié)構(gòu)式：

Molecular Weight: 308.3

CAS #: 55750-63-5

Spacer Length: 9.4 Å

Alternative Names: N-(epsilon-Malaimidocaproyloxy) succinimide

產(chǎn)品名稱：GMBS

簡介：GMBS is a non-cleavable heterobifunctional protein crosslinker. The GMBS crosslinking reagent is commonly used to crosslink haptens to carrier proteins and enzymes to antibody. The GMBS has a spacer arm length of 7.3 angstroms and is less immunogenic than the crosslinking analog MBS. The GMBS crosslinking reagent's NHS ester and maleimide reactive groups react with amino and sulfhydryl moites, respectively.

結(jié)構(gòu)式：

Molecular Weight: 280.2

CAS #: 80307-12-6

Spacer Length: 7.3 Å

Alternative Name: 4-Maleimdobutyric acid N-succinimidyl ester

產(chǎn)品名稱：LC-SPDP

簡介：LC-SPDP crosslinker is a cleavable, water insoluble, amino and thiol (sulfhydryl) reactive het-erobifunctional protein crosslinker. The "long chain" LC-SPDP crosslinking reagent has a 15.7 angstrom spacer arm, compared to the 6.8 angstrom spacer arm of SPDP.

結(jié)構(gòu)式：

Molecular Weight: 425.5

Spacer Length: 15.7 Å

Alternative Name: Succinimidyl-6-(3-[2-pyridyldithiol-propionamido) hexanoate

產(chǎn)品名稱：MBS

簡介：MBS crosslinker is a non-cleavable, water insoluble, heterobifunctional protein crosslinking rea-gent that is commonly used to crosslink haptens to carrier proteins and enzymes to antibody. The MBS crosslinking reagent's NHS ester and maleimide reactive groups react with amino and sulfhydryl moites, respectively.

結(jié)構(gòu)式：

Molecular Weight: 314.3

CAS #: 58626-38-3

Spacer Length: 7.3 Å

產(chǎn)品名稱：PDPH

簡介：PDPH is a cleavable, heterobifunctional protein crosslinking reagent. The PDPH crosslinker's hydrazide group selectively reacts with oxidized carbohydrates (or carboxyls when used with EDC); while the pyridinyldisulfide moiety is reactive toward reduced thiols. Thus, PDPH protein crosslinker is an excellent choice for crosslinking glycoproteins and other polysaccharides.

結(jié)構(gòu)式：

Molecular Weight: 229.3

Spacer Length: 9.2 Å

Alternative Name: 3-[2-Pyridyldithio]propionyl hydrazide

產(chǎn)品名稱：SBA

簡介：SBA crosslinker (N-Succinimidyl bromoacetate) is a sulfhydryl (thiol) and amino reactive hetero-bifunctional protein crosslinking reagent. SBA crosslinker is non-cleavable and is among the shortest amine and sulfhydryl reactive crosslinking reagents known with a spacer arm length of only 1.5 Angstroms.

Molecular Weight: 236.02

CAS #: 42014-51-7

Spacer Length: 1.5 Å

Alternative Names: Bromoacetic acid N-hydroxysuccinimide ester;

產(chǎn)品名稱：SIA

簡介：N-Succinimidyl iodoacetate (SIA) is a non-cleavable, heterobifunctional protein crosslinker. SIA is among the shortest amine and sulfhydryl (thiol) reactive crosslinkers known with a spacer arm length of 1.5 Angstroms.

Molecular Weight: 283.02

CAS #: 39028-27-8

Spacer Length: 1.5 Å

Alternative Names: Iodoacetic acid N-hydroxysuccinimide ester; Succinimidyl iodoacetate

產(chǎn)品名稱：SMCC

簡介：SMCC crosslinker (Succinimidyl-4-[N-maleimidomethyl]cyclohexane-1-carboxylate) is a heterobi-functional protein crosslinker with a maleimide group that is sulfhydryl (thiol; -SH) reactive and a NHS ester group that is amine reactive. The SMCC crosslinking reagent is permeable across the lipid bilayer of the cell membrane. The 9 atom spacer arm of SMCC is not cleavable.

Molecular Weight: 334.3

CAS #: 64987-85-5

Spacer Length: 8.3 Å

Alternative Names: 4-(N-Maleimidomethyl)cyclohexanecarboxylic acid N-hydroxysuccinimide ester;

產(chǎn)品名稱：SMPB

簡介：SMPB crosslinker (N-Succinimidyl 4-[4-maleimidophenyl]butyrate) is a heterobifunctional pro-tein crosslinking reagent that is reactive toward sulfhydryl and amino groups. The SMPB pro-tein crosslinker is an extended chain length analog of MBS crosslinker.

Molecular Weight: 356.3

CAS #: 79886-55-8

Spacer Length: 11.6 Å

Alternative Name: 4-(4-Maleimidophenyl)butyric acid N-hydroxysuccinimide ester

產(chǎn)品名稱：SMPH

簡介：SMPH crosslinker (Succinimidyl-6-[ß-maleimidopropionamido]hexanoate) is a water insoluble, heterobifunctional protein crosslinker with a non-cleavable spacer arm length of 14.3 angstroms. The SMPH crosslinking reagent has maleimide groups which are reactive to thiols (sufhydryls) and its NHS ester groups react with amines at pH 6.5-7.5 and 7-9, respectively

結(jié)構(gòu)式：

Molecular Weight: 379.4

Alternative Name: Succinimidyl-6-[βmaleimidopropionamido] hexanoate

產(chǎn)品名稱：SPDP

簡介：SPDP crosslinker is a cleavable, water insoluble, amino and thiol (sulfhydryl) reactive heterobi-functional protein crosslinker. The SPDP crosslinking reagent's reactive moites consist of an N-hydroxysuccinimide (NHS) ester that reacts with primary amines. On the other end of SPDP, the pyridinyldisulfide reacts with sulhydryls to yield a reversible disulfide bond.

Molecular Weight: 312.4

CAS #: 68181-17-9

Spacer Length: 6.8 Å

Alternative Name: 3-(2-Pyridyldithio)propionic acid N-hydroxysuccinimide ester

產(chǎn)品名稱：Sulfo-LC-SPDP

簡介：Sulfo-LC-SPDP crosslinking reagent is a cleavable, water soluble, amino and thiol (sulfhydryl) reactive heterobifunctional protein crosslinker.

Sulfo-LC-SPDP crosslinker's reactive moites consist of an N-hydroxysulfosuccinimide (Sulfo-NHS) ester that reacts with primary amines. The other end of the Sulfo-LC-SPDP crosslinking molecule pyridinyldisulfide reacts with sulhydryls to yield a reversible disulfide bond.

Molecular Weight: 527.6

Spacer Length: 15.7 Å

Alternative Name: Sulfosuccinimidyl-6-(3’-[2-pyridyldithio]-propionamido) hexanoate

產(chǎn)品名稱：Sulfo-MBS

簡介：Sulfo-MBS crosslinker (m-Maleimidobenzoyl-N-hydroxysulfosuccinimide ester) is a non-cleavable, water soluble, heterobifunctional protein crosslinking reagent that is commonly used to crosslink haptens to carri-er proteins and enzymes to antibody. The Sulfo-MBS crosslinking reagent's NHS ester and maleimide reac-tive groups react with amine and sulfhydryl moites, respectively.

Molecular Weight: 416.3

Spacer Length: 7.3 Å

Alternative Names: 3-Maleimidobenzoic acid N-hydroxysulfosuccinimide ester;

產(chǎn)品名稱：Sulfo-SANPAH

簡介：Sulfo-SANPAH crosslinker (N-Sulfosuccinimidyl-6-[4'-azido-2'-nitrophenylamino] hexanoate) is a water soluble, heterobifunctional protein crosslinker with a spacer arm length of 18.2 Å. Sul-fo-SANPAH crosslinking reagent contains an NHS ester that reacts with primary amines and a nitrophenylazide group that is photoreactive at 320-350 nm toward amino groups.

Molecular Weight: 492.4

CAS #: 102568-43-4

Spacer Length: 18.2 Å

產(chǎn)品名稱：Sulfo-SMCC

Sulfo-SMCC crosslinker (Sulfosuccinimidyl-4-[N-maleimidomethyl]cyclohexane-1-carboxylate) is a water soluble, heterobifunctional crosslinker. Sulfo-SMCC crosslinking reagent has an 8.3 angstrom non-cleavable spacer arm and its maleimide group reacts with sulfhydryls (thiols), while the Sulfo-NHS ester is reactive toward primary amines. Sulfo-SMCC can be used to pro-duce antibody-protein crosslinked conjugates or efficiently label cell surface proteins.

Molecular Weight: 436.4

CAS #: 92921-24-9

Spacer Length: 8.3 Å

Deuterated Crosslinkers氘代交聯(lián)劑產(chǎn)品：

產(chǎn)品名稱：BS2G-d4

BS2G-d4 deuterated crosslinker, Bis(Sulfosuccinimidyl) 2,2,4,4-glutarate-d4, is a water soluble and cell membrane impermeable crosslinking agent with 4 deuterium atoms to provide a 4 dal-ton shift by mass spectrometry analysis. Use BS2G-d4 crosslinking reagent in combination with the non-deuterated form of BS2G c1126-100mg or c1126-1gm for mass spectrometry studies.

Molecular Weight: 534.37

Spacer Length: 7.7 Å

Alternative Names: Glutaric acid-2,2,4,4-d4 bis (3-sulfo-N-hydroxysuccinimide ester) disodium salt

BS3-d4

BS3-d4 deuterated crosslinker, Bis(Sulfosuccinimidyl) 2,2,7,7-suberate-d4, is a water soluble and membrane impermeable crosslinking agent with 4 deuterium atoms to provide a 4 dalton shift by mass spectrometry. Use in combination with non-deuterated BS3 c1103-100mg or c1103-1gm for mass spectrometry studies.

Molecular Weight: 576.45

Spacer Length: 11.4 Å

Alternative Names: Suberic acid-2,2,7,7-d4 bis (3-sulfo-N-hydroxysuccinimide ester) disodium salt;

DSG-d4

DSG-d4 deuterated protein crosslinker (Bis[Succinimidyl] 2,2,4,4-glutarate-d4) is a cell mem-brane permeable crosslinking agent with 4 deuterium atoms to provide a 4 dalton shift by mass spectrometry analysis. Use the DSG-d4 heavy protein crosslinker in combination with the light, non-deuterated analog DSG (c1104).for mass spectrometry studies.

Molecular Weight: 330.28

Spacer Length: 7.7Å

Alternative Names: Glutaric acid-2,2,4,4-d4 bis (N-hydroxysuccinimide ester);

DSS-d4

DSS-d4 deuterated crosslinker (Bis[Succinimidyl] 2,2,7,7-suberate-d4) is a cell membrane perme-able crosslinking agent with 4 deuterium atoms that provide a 4 dalton shift by mass spectrome-try analysis. Use DSS-d4 heavy crosslinker in combination with DSS, the light non-deuterated analog c1105-100mg or c1105-1gm, for mass spec studies.

Molecular Weight: 372.36

Spacer Length: 11.4 Å

Alternative Names: Suberic acid-2,2,7,7-d4 bis (N-hydroxysuccinimide ester);

DSP-d8

DSP-d8 deuterated protein crosslinker, Dithiobis(succinimidyl 2,2,3,3,6,6,7,7-propionate-d8), is a cell membrane permeable, homobifunctional protein crosslinker containing 8 deuterium atoms to provide an 8 dalton shift by mass spectrometry compared to non-deuterated DSP. DSP-d8 has amine-reactive NHS esters at both ends of a cleavable, 8-atom (12.0 angstrom) spacer arm. DSP-d8 contains a reducible disulfide bond (SS-bond) in the spacer arm. Use the DSP-d8 deuterated protein crosslinking reagent in combination with non-deuterated analog DSP for MS studies

Molecular Weight: 412.46

Spacer Length: 12.0 Å

Alternative Names: Dithiobis(succinimidyl) propionate-d8; DSP-d8

Biotinylation Reagents交聯(lián)試劑：

產(chǎn)品名稱：Biotin Hydrazide

Biotin Hydrazide (Biotin-Hz) is a carbohydrate reactive biotinylation reagent. Biotin Hydrazide is a great choice for labeling mouse monoclonal antibodies, lectins, sugars, unpaired cytosine residues in nucleic acids, and glycoprotiens. Typically, Biotin Hydrazide is used for coupling gly-coproteins through the carbohydrate by hydrazone formation.

Molecular Weight: 258.3

CAS #: 66640-86-6

Spacer Length: 15.7 Å

Alternative Name: (+)-Biotin Hydrazide

產(chǎn)品名稱：NHS-Biotin

NHS-Biotin (Succinimidyl Biotin; Succinimidobiotin) is a primary amine reactive biotinylation reagent. The NHS-Biotin molecule is cell membrane permeable and can be used to covalently label intracellular proteins.

Molecular Weight: 341.4

CAS #: 35013-72-0

Spacer Length: 13.5 Å

Alternative Names: Succinimidobiotin; Biotin-OSU; Biotin N-hydroxysuccinimide ester

產(chǎn)品名稱：NHS-SS-Biotin

NHS-SS-Biotin, Succinimidyl-2-(biotinamido)-ethyl-1,3'-dithiopropionate, is an amine-reactive biotinylation reagent that contains a reducible disulfide. NHS-SS-Biotin is cell membrane per-meable and has a long chain separating the biotin group from the amino-reactive NHS-ester (N-Hydroxysuccinimide ester). This product is often used to purify an antibody or other protein from a biotin specific affinity resin like immobilized streptavidin without exposing your protein of interest to denaturing conditions.

Molecular Weight: 504.7

CAS #: 142439-92-7

Spacer Length: 24.3 Å

Alternative Name: Biotin disulfide N-Hydroxysuccinimide ester

產(chǎn)品名稱：Sulfo-NHS-Biotin

Sulfo-NHS-Biotin (Sulfosuccinimidyl biotin) is a water soluble biotinylation reagent. It is amine reactive and has a spacer arm length of 13.5Å. The Sulfo-NHS-Biotin biotinylation reagent is ideal for biotinylating antibody or protein that can then be used for protein detection or immobi-lization. Sulfo-NHS-Biotin is particularly useful for targeting cell surface proteins.

Molecular Weight: 443.4

CAS #: 119616-92-5

Spacer Length: 13.5 Å

Alternative Names: Biotin 3-sulfo-N-hydroxysuccinimide ester sodium salt;

產(chǎn)品名稱：Sulfo-NHS-LC-Biotin

Sulfo-NHS-LC-Biotin, Sulfosuccinimidyl 6-(biotinamido) Hexanoate, is a long chain water solu-ble biotinylation reagent that is reactive toward primary amine groups. Similar to Sulfo-NHS-Biotin (b2100-100mg and b2100-1gm), Sulfo-NHS-LC-Biotin is designed to target cell surface proteins. The sodium sulfonate groups lend water solubility to Sulfo-NHS-LC-Biotin and prevent it from crossing the lipid bi-layer of the cell membrane.

Molecular Weight: 556.6

CAS #: 128062-22-0

Spacer Length: 22.4 Å

Alternative Name: Biotinamidohexanoic acid 3-sulfo-N-hydroxysuccinimide ester sodium salt

產(chǎn)品名稱：Sulfo-NHS-SS-Biotin

Sulfosuccinimidyl-2-(biotinamido)-ethyl-1,3'-dithiopropionate (Sulfo-NHS-SS-Biotin) is a cleava-ble, water-soluble, amino-reactive biotinylation reagent. This molecule is cell membrane imper-meable due to its sodium sulfonate group. Sulfo-NHS-SS-Biotin has a long chain spacer arm sep-arating the biotin group from the amino-reactive sulfo-NHS ester moity. It is possible to cleave the biotin group from the crosslinked target protein under reducing conditions, such as in the presence of BME, DTT or TCEP.

Molecular Weight: 606.7

CAS #: 202057-28-1

Spacer Length: 24.3 Å

Alternative Name: Biotin disulfide N-Hydroxysulfosuccinimide ester

Other Modifications其他交聯(lián)劑產(chǎn)品：

產(chǎn)品名稱：HPG

HPG protein modification reagent (p-Hydroxyphenylglyoxal) reacts with arginine residues to give a large increase in absorbance at approximay 340 nm. The HPG is a better choice for ami-no acid side chain modification due to its increased water solubility over phenylglyoxal and im-proved oxidation resistance over p-nitrophenylglyoxal. Chemical Formula: C8H8O4

Molecular Weight: 168.2

CAS #: 24645-80-5

Alternative Names: p-Hydroxyphenylglyoxal monohydrate; 4-hydroxyphenylglyoxal;

產(chǎn)品名稱：SATA

SATA (N-Succinimidyl-S-Acetyl-Thioacetate) is a protein modification reagent used to convert primary amine groups into protected sulfhydryls (thiol; -SH). The sulfhydryl is readily made available for use in subsequent reactions after exposure to hydroxylamine.

CAS #: 76931-93-6

Molecular Weight: 231.2

Alternative Names: S-Acetylthioglycolic acid N-hydroxysuccinimide ester

產(chǎn)品名稱：Sulfo-NHS Acetate

Sulfo-NHS-Acetate acylating agent (Sulfosuccinimidyl Acetate) is a water soluble. Sulfo-NHS-Acetate irreversibly reacts with primary amines, such as in lysine, at pH greater than 7 to yield the acylated form. Using Sulfo-NHS Acetate prevents polymerization when performing protein crosslinking reactions.

Molecular Weight: 259.17

CAS #: 152305-87-8

Alternative Names: 1-acetyloxy-2,5-dioxopyrrolidine-3-sulfonic acid

產(chǎn)品列表：

Sulfo-NHS    CAS #: 106627-54-7

BS3        CAS #: 82436-77-9

BS2G

BSG              CAS #: 79642-50-5

DSP        CAS #: 57757-57-0

DSS        CAS #: 68528-80-3

DTSSP           CAS #: 81069-02-5

EGS              CAS #: 70539-42-3

Sulfo-EGS    

DSSeb           CAS # 23024-29-5

BMPS            CAS #: 55750-62-4

EMCS            CAS #: 55750-63-5

GMBS           CAS #: 80307-12-6

LC-SPDP             

MBS              CAS #: 58626-38-3

PDPH           

SBA              CAS #: 42014-51-7     

SIA        CAS #: 39028-27-8

SMCC            CAS #: 64987-85-5

SMPB            CAS #: 79886-55-8

SMPH           

SPDP             CAS #: 68181-17-9

Sulfo-LC-SPDP    

Sulfo-MBS    

Sulfo-SANPAH     CAS #: 102568-43-4

Sulfo-SMCC   CAS #: 92921-24-9

BS2G-d4

BS3-d4

DSG-d4

DSS-d4

DSP-d8

Biotin Hydrazide CAS #: 66640-86-6

NHS-Biotin    CAS #: 35013-72-0

NHS-SS-Biotin      CAS #: 142439-92-7

Sulfo-NHS-Biotin CAS #: 119616-92-5

Sulfo-NHS-LC-Biotin    CAS #: 128062-22-0

Sulfo-NHS-SS-Biotin    CAS #: 202057-28-1

HPG              CAS #: 24645-80-5

SATA            CAS #: 76931-93-6

Sulfo-NHS Acetate CAS #: 152305-87-8

以上資料源于西安瑞禧生物科技有限公司

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