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產(chǎn)品名稱：PDPH

英文全稱：(3-(2-pyridyldithio)propionyl hydrazide)

簡介：PDPH is a cleavable, heterobifunctional protein crosslinking reagent. The PDPH crosslinker's hydrazide group selectively reacts with oxidized carbohydrates (or carboxyls when used with EDC); while the pyridinyldisulfide moiety is reactive toward reduced thiols. Thus, PDPH protein crosslinker is an excellent choice for crosslinking glycoproteins and other polysaccharides.

General description

The PDPH is a heterobifunctional crosslinker containing sulfhydryl-reactive pyridyldithiol and carbonyl-reactive hydrazide moieties. Pyridyldithiols react with free sulfhydryls (-SH) to form disulfide bonds. Hydrazide groups react with carbonyls (aldehydes and ketones) to form stable hydrazone bonds. Aldehyde groups can be created by periodate-oxidation of sialic acid and other sugar components of glycoprotein polysaccharides. Thus, PDPH is useful for conjugating glycoproteins and sulfhydryl-containing peptides or proteins. Likewise, PDPH is useful as a sulfhydryl-addition reagent for glycoproteins and other carbohydrates; after reaction of the hydrazide to an oxidized carbohydrate, the pyridyldithiol group can be cleaved by a reducing agent to expose a sulfhydryl group. Yet another application for PDPH is to react the primary amine of the hydrazide moiety to a carboxyl group using the crosslinker EDC.

外觀：白色粉末

Molecular Weight: 229.3

分子式：C8N3S2OH11  

溶解性：DMSO or DMF

Spacer Length: 9.2 Å

Alternative Name: 3-[2-Pyridyldithio]propionyl hydrazide

純度：98%+

保存：-20℃

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Features and Benefits

• Reactive groups: pyridyldisulfide and hydrazide

• Reactive toward: sulfhydryl groups and carbonyl (aldehyde) groups

• Short (9.2A), sulfhydryl-to-aldehyde crosslinker with disulfide bond spacer arm (cleavable)

• Pyridyldithiol group results in attachment to sulfhydryls via disulfide bond, which can be cleaved with DTT, TCEP or other reducing agents

• Hydrazide group conjugates to oxidized sugars of glycoproteins and carbohydrates

• Use sodium meta-periodate to oxidize glycosylation (e.g., sialic acid) to reactive aldehyde groups

• Use with EDC to conjugate primary amine of hydrazide group to carboxyl groups

產(chǎn)品名稱：

英文名稱：Bromoacetic Acid N-Succinimidyl Ester

中文名稱：溴乙酸-N-琥珀酰亞胺酯

CAS #: 42014-51-7

簡介：SBA crosslinker (N-Succinimidyl bromoacetate) is a sulfhydryl (thiol) and amino reactive hetero-bifunctional protein crosslinking reagent. SBA crosslinker is non-cleavable and is among the shortest amine and sulfhydryl reactive crosslinking reagents known with a spacer arm length of only 1.5 Angstroms.

A heterobifunctional cross-linking reagent which allows bromoacetylation of primary amine groups followed by coupling to sulfhydryl-containing compounds. Typically, initial reaction couples via ester to primary amine by amide bond formation in the pH range 6.5-8.5. The second reaction results in thioether bonding in pH range 7.0-8.0.

外觀：白色粉末

Molecular Weight: 236.02

分子式:C6H6BrNO4

CAS #: 42014-51-7

Spacer Length: 1.5 Å

Alternative Names: Bromoacetic acid N-hydroxysuccinimide ester;

純度：98%+

保存：-20℃

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以上資料源于西安瑞禧生物科技有限公司

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