英文名稱 APPBP2
中文名稱 β淀粉樣蛋白前體蛋白結(jié)合蛋白2抗體
別    名 amyloid beta precursor protein (cytoplasmic tail) binding protein 2; Amyloid beta precursor protein-binding protein 2; Amyloid protein binding protein 2; Amyloid protein-binding protein 2; APBP2_HUMAN; APP BP2; APP-BP2; Appbp2; PAT1; Ara67 Protein interacting with APP tail 1.
β淀粉樣蛋白前體蛋白結(jié)合蛋白2抗體 
說(shuō) 明 書 0.2ml  
研究領(lǐng)域 免疫學(xué)  神經(jīng)生物學(xué)  Alzheimer's  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Dog, Pig, Cow, Zebrafish, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 67kDa
細(xì)胞定位 細(xì)胞核 細(xì)胞漿 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human APPBP2
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
β淀粉樣蛋白前體蛋白結(jié)合蛋白2抗體產(chǎn)品介紹 background:
The protein encoded by this gene interacts with microtubules and is functionally associated with beta-amyloid precursor protein transport and/or processing. The beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. This gene has been found to be highly expressed in breast cancer. Multiple polyadenylation sites have been found for this gene. [provided by RefSeq, Jul 2008].

Function:
May play a role in intracellular protein transport. May be involved in the translocation of APP along microtubules toward the cell surface.

Subunit:
Binds APP.

Subcellular Location:
Nucleus. Cytoplasm

Post-translational modifications:
Rapidly degraded by the proteasome upon overexpression of a C-terminal fragment of APP.

Similarity:
Contains 8 TPR repeats.

Database links:

Entrez Gene: 10513 Human

Entrez Gene: 66884 Mouse

Entrez Gene: 303396 Rat

Entrez Gene: 417645 Chicken

Omim: 605324 Human

SwissProt: Q92624 Human

SwissProt: Q9DAX9 Mouse

SwissProt: A5HK05 Rat

Unigene: 84084 Human

Unigene: 271997 Mouse

Unigene: 104856 Rat

Important Note:
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