英文名稱 phospho-alpha Adducin(Ser436)
中文名稱 磷酸化內(nèi)收蛋白a1抗體
別    名 alpha Adducin(phospho S436); alpha Adducin(phospho Ser436); p-alpha Adducin(S436); p-alpha Adducin(Ser436); ADD 1; ADD A; ADD1; ADD1 protein; ADDA; ADDA_HUMAN; Adducin 1 (alpha); Adducin 1 alpha; Alpha adducin; Alpha-adducin; Erythrocyte adducin alpha subunit; Erythrocyte hosphor subunit alpha; Erythrocyte adducin subunit alpha.
磷酸化內(nèi)收蛋白a1抗體  
說 明 書 0.1ml  
產(chǎn)品類型 磷酸化抗體 
研究領域 細胞生物  信號轉(zhuǎn)導  激酶和磷酸酶  細胞骨架  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse, Rat, Chicken, Dog, Cow, Horse, 
產(chǎn)品應用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 81kDa
細胞定位 細胞漿 細胞膜 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthesised phosphopeptide derived from human alpha Adducin around the phosphorylation site of Ser436
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Adducins are a family of cytoskeleton proteins encoded by three genes (Alpha, Beta, Gamma). Adducin is a protein associated with the inner leaflet of the plasma membrane and is one of the proteins localized at the spectrin-actin junction of the membrane skeleton. The cortical actin cytoskeletal network is lost during apoptosis and Adducins are central in the cortical actin network organization. Adducin Alpha is a cytoskeletal protein involved with sodium-pump activity in the renal tubule and is associated with hypertension. The expression of Adducin Alpha and Adducin Gamma is ubiquitous in contrast to the restricted expression of Adducin Beta. Adducin Beta is expressed at high levels in brain and hematopoietic tissues, such as bone marrow, in humans, and in spleen in mice.

Function:
Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin.

Subunit:
Heterodimer of an alpha and a beta subunit or an alpha and a gamma subunit.

Subcellular Location:
Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side.

Tissue Specificity:
Expressed in all tissues. Found in much higher levels in reticulocytes than the beta subunit.

Similarity:
Belongs to the aldolase class II family. Adducin subfamily.

Database links:
UniProtKB/Swiss-Prot: P35611.2

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.xy-5613R phospho-PTK9 (Tyr321)磷酸化蛋白酪氨酸激酶9抗體
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