CD244抗體

抗原
CD244 Molecule, Natural Killer Cell Receptor 2B4 (CD244)
別名 CD244, 2B4, NAIL, NKR2B4, Nmrk, SLAMF4, C9.1, F730046O15Rik, Ly90
抗原表位
其他選擇 AA 1-221
pTyr271(13),C-Term (12),AA 1-221 (7),Extracellular Domain (5),Internal Region (3),AA 1-365 (1),AA 20-221 (1),AA 22-221 (1)
適用
其他選擇 Human
Human(95),Murine (43),Rat ((Rattus)) (22),Pig (Porcine) (12),Rabbit (1)
宿主
其他選擇 Rabbit
Rabbit(50),Mouse (38),Rat (19),Goat (10)
克隆類型
多克隆
標記
其他選擇 非結合性
PE(14),FITC (12),Biotin (10),Alexa Fluor 647 (4),Alexa Fluor 350 (2),Alexa Fluor 488 (2),Alexa Fluor 555 (2),CF (2),Cy3 (2),Cy5 (2),Cy5.5 (2),Cy7 (2),HRP (2)
zui低檢測濃度 0.00245 ng/well
應用范圍
其他選擇 ELISA
Flow Cytometry (FACS)(70),Western Blotting (WB) (41),ELISA (22),Immunofluorescence (Paraffin-embedded Sections) (IF (p)) (20),Immunoprecipitation (IP) (15),Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (9),Immunohistochemistry (IHC) (6),Functional Studies (Func) (3),Enzyme Immunoassay (EIA) (2),Immunofluorescence (IF) (2),Immunoassay (IA) (1),Immunocytochemistry (ICC) (1),Immunohistochemistry (Frozen Sections) (IHC (fro)) (1)
[Pubmed] 1 reference available
規(guī)格 100 μg
發(fā)貨至 中國 (更改)

CD244抗體

產(chǎn)品細節(jié)

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產(chǎn)品細節(jié)

顯示 隱藏
亞型 IgG
特異性 Human 2B4 / SLAMF4 / CD244
產(chǎn)品特性 Produced in rabbits immunized with purified, recombinant Human 2B4 (rh 2B4, NP_057466.1, Met 1-Arg 221). Total IgG was purified by Protein A affinity chromatography .
純化方法 Affinity Purified
過濾 0.2 μm filtered

目標詳細情況

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目標詳細情況

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別名 CD244
背景 The CD244 antigen, also known as 2B4, is a cell surface glycoprotein implicated in the regulation of natural killer and T lymphocyte function. 2B4 is a member of the signaling lymphocyte activation molecule (SLAM)-related receptor family and is important for stimulating NK cell cytotoxicity and cytokine production, which is expressed on all NK cells, a subpopulation of T cells, monocytes and basophils. The 2B4 antigen identified on NK cells and T cells is capable of transmitting stimulatory signals and non-MHC-restricted killing. Reported as an activating receptor, human 2B4 can effectively activate and enhance NK cell-mediated cytotoxicity, induce secretion of IFN-γ and matrix metalloproteinases (MMPs), as well as NK cell invasiveness. As a cell surface glycoprotein of the Ig-superfamily structurally related to CD2-like molecules such as CD2, CD48, CD58, CD84, Ly-9, and SLAM, 2B4 (CD244) is expressed on all human NK cells, a subpopulation of T cells, basophils and monocytes. 2B4 activates NK cell mediated cytotoxicity, induces secretion of IFN-gamma and matrix metalloproteinases, and NK cell invasiveness.
NCBI Accession NP_057466.1
研究領域 Stem Cells, Hematopoietic Progenitors, CD Antigens, Surface Receptors of Immune Cells

使用細節(jié)

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使用細節(jié)

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應用備注 ELISA ELISA: 0.5-1 μg/mL This antibody can be used at 0.5-1 μg/mL with the appropriate secondary reagents to detect Human 2B4. The detection limit for Human 2B4 is 0.00245 ng/well.
限制 For Research Use only

貯存及處理

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貯存及處理

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緩沖液 PBS with 5% trehalose
儲存液 Without preservative
注意事項 Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
儲存條件 4 °C/-20 °C/-80 °C
儲存方法 This antibody can be stored at 2 °C-8 °C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 °C to -70 °C.
有效期 12 months

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