IGFBP3 抗體

抗原
Insulin-Like Growth Factor Binding Protein 3 (IGFBP3)
別名 IGFBP-3, zgc:91788, IGFBP3, igfbp3, BP-53, IBP3, AI649005, IGgfbp3, IGF-BP3
抗原表位
其他選擇 AA 28-291
pSer183(10),N-Term (9),AA 28-291 (8),Ser183 (8),Internal Region (7),AA 185-189 (4),AA 137-274 (2),AA 151-291 (2),AA 163-193 (2),Middle Region (2),AA 1-291 (1),AA 106-241 (1),AA 130-179 (1),AA 135-232 (1),AA 151-200 (1),AA 162-189 (1),AA 84-291 (1),C-Term (1),His179 (1),Ser53 (1)
適用
其他選擇 Human
Human(112),Murine (42),Rat ((Rattus)) (24),Dog (Canine) (2),Bovine (1),Hamster (1)
宿主
其他選擇 Rabbit
Rabbit(105),Mouse (15),Goat (6),Rat (1)
克隆類型
多克隆
標(biāo)記
其他選擇 非結(jié)合性
Biotin(10),FITC (5),HRP (3),APC (2),Alkaline Phosphatase (AP) (2),PE (2),Alexa Fluor 350 (1),Alexa Fluor 488 (1),Alexa Fluor 555 (1),Alexa Fluor 647 (1),Cy3 (1),Cy5 (1),Cy5.5 (1),Cy7 (1)
zui低檢測(cè)濃度 0.00245 ng/well
應(yīng)用范圍
其他選擇 ELISA
Western Blotting (WB)(93),ELISA (67),Immunohistochemistry (IHC) (45),Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (22),Immunofluorescence (Paraffin-embedded Sections) (IF (p)) (10),Immunocytochemistry (ICC) (9),Enzyme Immunoassay (EIA) (8),Immunohistochemistry (Frozen Sections) (IHC (fro)) (7),Immunohistochemistry (Frozen Paraffin-embedded Sections) (IHC (frpe)) (3),Immunofluorescence (IF) (2),Immunoprecipitation (IP) (2),Blocking Antibody (Inhibition) (1),Immunoassay (IA) (1),Immunoradiometric Assay (IRMA) (1),Neutralization (Neut) (1),Radioimmunoassay (RIA) (1)
[Pubmed] 3 references available
規(guī)格 100 μg
發(fā)貨至 中國(guó) (更改)

IGFBP3 抗體

產(chǎn)品細(xì)節(jié)

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產(chǎn)品細(xì)節(jié)

顯示 隱藏
亞型 IgG
特異性 Human IGFBP3
產(chǎn)品特性 Produced in rabbits immunized with purified, recombinant Human IGFBP3 (rh IGFBP3, NP_000589.2, Gly 28-Lys 291). Total IgG was purified by Protein A affinity chromatography.
純化方法 Affinity Purified
過(guò)濾 0.2 μm filtered

目標(biāo)詳細(xì)情況

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目標(biāo)詳細(xì)情況

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別名 IGFBP3
背景 The Insulin-like Growth Factor (IGF) signaling system plays a central role in cellular growth, differentiation and proliferation. IGFBP3 is the most abundant IGF binding protein in human serum and has been shown to be a growth inhibitory, apoptosis-inducing molecule, capable of acting via IGF-dependent and IGF-independent mechanisms. It appears to function both by cell cycle blockade and the induction of apoptosis. IGFBP3 can be transported to the nucleus by an importin beta mediated mechanism, where it has been shown to interact with the retinoid X receptor alpha and possibly other nuclear elements. IGFBP3 antiproliferative signalling appears to require an active transforming growth factor beta (TGF-beta) signalling pathway, and IGFBP3 stimulates phosphorylation of the TGF-beta signalling intermediates Smad2 and Smad3. IGFBP3 has IGF- independent roles in inhibiting cell proliferation in cancer cell lines. Nuclear transcription factor, retinoid X receptor (RXR)-alpha, and IGFBP3 functionally interact to reduce prostate tumor growth and prostate-specific antigen in vivo. Several clinical studies have proposed that individuals with IGFBP3 levels in the upper range of normal may have a decreased risk for certain common cancers. This includes evidence of a protective effect against breast cancer, prostate cancer, colorectal cancer, and lung cancer. Moreover, IGFBP3 inhibits insulin-stimulated glucose uptake into adipocytes independent of IGF.
NCBI Accession NP_000589.2
研究領(lǐng)域 Cardiovascular, Atherosclerosis, Angiogenesis, Apoptosis/Necrosis, Hormones, Diabetes, Metabolism, Growth Factors

使用細(xì)節(jié)

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使用細(xì)節(jié)

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應(yīng)用備注 ELISA ELISA: 0.5-1 μg/mL This antibody can be used at 0.5-1 μg/mL with the appropriate secondary reagents to detect Human IGFBP3. The detection limit for Human IGFBP3 is approximay 0.00245 ng/well.
限制 For Research Use only

貯存及處理

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貯存及處理

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緩沖液 PBS with 5% trehalose
儲(chǔ)存液 Without preservative
注意事項(xiàng) Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
儲(chǔ)存條件 4 °C/-20 °C/-80 °C
儲(chǔ)存方法 This antibody can be stored at 2 °C-8 °C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 °C to -70 °C.
有效期 12 months

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