ARSA 抗體

抗原
Arylsulfatase A (ARSA)
別名 ARSA, zgc:101575, arsa, AS-A, ASA, AW212749, As-2, As2, TISP73, MLD, mld
抗原表位
其他選擇 AA 1-507
C-Term(13),AA 1-507 (10),Internal Region (9),AA 1-506 (6),AA 408-439 (4),N-Term (3),Middle Region (2),AA 10-256 (1),AA 169-405 (1),AA 251-300 (1),AA 301-493 (1),AA 45-249 (1)
適用
其他選擇 Human
Human(84),Murine (51),Rat ((Rattus)) (43),Bovine (15),Dog (Canine) (15),Pig (Porcine) (14),Guinea Pig (1),Rabbit (1),Xenopus laevis (1)
宿主
其他選擇 Rabbit
Rabbit(69),Mouse (15),Goat (7)
克隆類型
多克隆
標記
其他選擇 非結合性
Biotin(3),FITC (3),HRP (3),Alexa Fluor 350 (2),Alexa Fluor 488 (2),Alexa Fluor 555 (2),Alexa Fluor 647 (2),Cy3 (2),Cy5 (2),Cy5.5 (2),Cy7 (2),APC (1),Alkaline Phosphatase (AP) (1),PE (1)
zui低檢測濃度 0.039 ng/well
應用范圍
其他選擇 ELISA
Western Blotting (WB)(64),ELISA (37),Immunohistochemistry (IHC) (20),Immunofluorescence (Paraffin-embedded Sections) (IF (p)) (19),Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (7),Immunoassay (IA) (3),Immunoprecipitation (IP) (2),Immunofluorescence (IF) (1)
[Pubmed] 1 reference available
規(guī)格 100 μg
發(fā)貨至 中國 (更改)

ARSA 抗體

產(chǎn)品細節(jié)

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產(chǎn)品細節(jié)

顯示 隱藏
亞型 IgG
特異性 Human Arylsulfatase-A / ARSA
產(chǎn)品特性 Produced in rabbits immunized with purified, recombinant Human ARSA (rh ARSA, NP_000478.2, Met 1-Ala 507). Total IgG was purified by Protein A affinity chromatography .
純化方法 Affinity Purified
過濾 0.2 μm filtered

目標詳細情況

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目標詳細情況

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別名 ARSA
背景 Arylsulfatase A (ARSA) is synthesized as a 52KDa lysosomal enzyme. It is a member of the sulfatase family that is required for the lysosomal degradation of cerebroside-3-sulfate, a sphingolipid sulfate ester and a major constituent of the myelin sheet. Arylsulfatase A is activated by a required co- or posttranslational modification with the oxidation of cysteine to formylglycine. Metachromatic leukodystrophy (MLD) is a lysosomal storage disease in the central and peripheral nervous systems with severe and progressive neurological symptoms caused by the deficiency of Arylsulfatase A. Deficiency of this enzyme is also found in apparently healthy individuals, a condition for which the term pseudodeficiency is introduced. ARSA forms dimers after receiving three N-linked oligosaccharides in the endoplasmic reticulum, and then the dimers are transported to the Golgi where they receive mannose 6-phosphate recognition markers. And thus, ARSA is transported and delivered to dense lysosomes in a mannose 6-phosphate receptor-dependent manner. It has been shown that within the lysosomes, the ARSA dimers can oligomerize to an octamer in a pH-dependent manner. The ARSA deficiency leads to metachromatic leucodystrophy (MLD), a lysosomal storage disorder associated with severe and progressive demyelination in he central and peripheral nervous system. Additionally, the serum level of arylsulfatase A might be helpful in diagnosis of lung and central nervous system cancer.
NCBI Accession NP_000478.2
研究領域 Cancer, Organelles

使用細節(jié)

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使用細節(jié)

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應用備注 ELISA ELISA: 0.5-1 μg/mL This antibody can be used at 0.5-1 μg/mL with the appropriate secondary reagents to detect Human ARSA. The detection limit for Human ARSA is 0.039 ng/well.
限制 For Research Use only

貯存及處理

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貯存及處理

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緩沖液 PBS with 5% trehalose
儲存液 Without preservative
注意事項 Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
儲存條件 4 °C/-20 °C/-80 °C
儲存方法 This antibody can be stored at 2 °C-8 °C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 °C to -70 °C.
有效期 12 months

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