PTPN2抗體

抗原
Protein tyrosine Phosphatase, Non-Receptor Type 2 (PTPN2)
別名 PTN2, PTPT, TC-PTP, TCELLPTP, TCPTP, AI325124, Ptpt, PTP-1B, cb806, ptpn2, ptpn2l, wu:fc10h07, zgc:55339, zgc:76973
抗原表位
其他選擇 N-Term
AA 328-358(7),C-Term (6),N-Term (5),AA 1-387 (3),Middle Region (2),AA 1-263 (1),AA 149-402 (1),AA 330-344 (1),AA 369-382 (1),Internal Region (1)
適用
其他選擇 Human
Human(34),Murine (10),Rat ((Rattus)) (10),Bovine (2),Dog (Canine) (2),Xenopus laevis (2),Zebrafish (Danio rerio) (2),Chicken (1),Fruit Fly (Drosophila melanogaster) (1)
宿主
其他選擇 Rabbit
Rabbit(31),Mouse (3)
克隆類型
多克隆
標記
其他選擇 非結合性
APC(1),Alkaline Phosphatase (AP) (1),Biotin (1),FITC (1),HRP (1),PE (1)
應用范圍
其他選擇 Western Blotting (WB)
Western Blotting (WB)(31),Immunohistochemistry (IHC) (16),ELISA (15),Immunoassay (IA) (3),Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (2),Immunoprecipitation (IP) (2)
規(guī)格 50 μg
發(fā)貨至 中國 (更改)
發(fā)貨時間 9至12個工作日

PTPN2抗體

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產品細節(jié)

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免疫原 Synthetic peptide directed towards the N terminal of human PTPN2
序列 MPTTIEREFE ELDTQRRWQP LYLEIRNESH DYPHRVAKFP ENRNRNRYRD
預測反應 Guinea pig : 100 %, Horse : 100 %, Human : 100 %, Mouse : 100 %, Rabbit : 100 %, Rat : 100 %, Bovine : 90 %, Chicken : 70 %
產品特性 This is a rabbit polyclonal antibody against PTPN2. It was validated on Western Blot using a cell lysate as a positive control.
純化方法 Affinity Purified

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別名 PTPN2
背景 PTPN2 is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling.The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Three alternatively spliced variants of this gene, which encode isoforms differing at their extreme C-termini, have been described. The different C-termini are thought to determine the substrate specificity, as well as the cellular localization of the isoforms. Two highly related but distinctly processed pseudogenes that localize to distinct chromosomes have been reported.
分子量 48 kDa
基因ID 5771
NCBI Accession NP_002819, NM_002828
UniProt P17706

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應用備注 Optimal working dilutions should be determined experimentally by the investigator.
說明

Antigen size: 415 AA

限制 For Research Use only

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狀態(tài) Lyophilized
溶解方式 Add 50 μL of distilled water.
濃度 1 mg/mL
緩沖液 PBS buffer with 2 % sucrose
注意事項 Avoid repeated freeze-thaw cycles.
儲存條件 -20 °C

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