SIGLEC11抗體

抗原
Sialic Acid Binding Ig-Like Lectin 11 (SIGLEC11)
抗原表位
其他選擇 C-Term
C-Term(15),N-Term (6),AA 631-662 (2)
適用
其他選擇 Human
Human(38),Murine (13),Rat ((Rattus)) (13)
宿主
其他選擇 Rabbit
Rabbit(36),Goat (1),Mouse (1)
克隆類型
多克隆
標(biāo)記
其他選擇 非結(jié)合性
PE(4),Biotin (3),FITC (3),HRP (3),APC (2),Alkaline Phosphatase (AP) (2),Alexa Fluor 350 (1),Alexa Fluor 488 (1),Alexa Fluor 555 (1),Alexa Fluor 647 (1),Cy3 (1),Cy5 (1),Cy5.5 (1),Cy7 (1)
應(yīng)用范圍
其他選擇 Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Paraffin-embedded Sections) (IHC (frpe)), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Immunohistochemistry (IHC)(22),ELISA (21),Western Blotting (WB) (14),Flow Cytometry (FACS) (12),Immunofluorescence (Paraffin-embedded Sections) (IF (p)) (10),Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (4),Immunoassay (IA) (1)
[Pubmed] 2 references available
規(guī)格 0.1 mg
發(fā)貨至 中國 (更改)
發(fā)貨時間 29至35個工作日

SIGLEC11抗體

產(chǎn)品細(xì)節(jié)

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產(chǎn)品細(xì)節(jié)

顯示 隱藏
免疫原 Siglec11 antibody was raised against an 18 amino acid peptide from near the carboxy terminus of human Siglec11.
亞型 IgG
特異性 This antibody detects Siglec11. It will not cross-react with Siglec10. Despite its predicted size, Siglec11 migrates at a higher than expected molecular weight in SDS-PAGE.
交叉反應(yīng) （詳細(xì)） Species reactivity (tested):Human
純化方法 Peptide affinity chromatography

目標(biāo)詳細(xì)情況

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目標(biāo)詳細(xì)情況

顯示 隱藏
別名 SIGLEC11
背景 Siglecs are sialic acid-binding lectins of the immunoglobulin superfamily that are mainly expressed in cells of the hematopoietic system. Siglec11 is unlike other siglecs in that it binds specifically to a2-8-linked sialic acids and is not found in peripheral blood leukocytes but instead on macrophages of various tissues. Siglec11 is highly homologous to Siglec10 over their extracellular domain but not over their cytoplasmic domain, suggesting that Siglec11 arose through gene duplication followed by a recombination event involving another ancestral siglec gene. Following treatment of Siglec11-transfected cells with pervanadate, Siglec11 becomes tyrosine-phosphorylated and strongly associates with SHP-1 and SHP-2. At least five isoforms of Siglec11 are known to exist.Synonyms: SIGLEC-11, Sialic acid-binding Ig-like lectin 11, Sialic acid-binding lectin 11, UNQ9222/PRO28718
基因ID 114132
NCBI Accession NP_443116
UniProt Q96RL6
研究領(lǐng)域 Innate Immunity

使用細(xì)節(jié)

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使用細(xì)節(jié)

顯示 隱藏
應(yīng)用備注 ELISA. Western blot: 0.5 - 1?μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
限制 For Research Use only

貯存及處理

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貯存及處理

顯示 隱藏
緩沖液 PBS containing 0.02?% sodium azide
儲存液 Sodium azide
注意事項 This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
注意事項 Avoid repeated freezing and thawing.
儲存條件 4 °C/-20 °C

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