C1q A Subunit 抗體

抗原
C1q A Subunit
適用
其他選擇 Human, Murine, Rat ((Rattus))
Human(18),Murine (3),Rat ((Rattus)) (2)
宿主
其他選擇 Mouse
Mouse(8),Rabbit (5),Sheep (4),Goat (1),Rat (1)
克隆類(lèi)型 (克隆位點(diǎn))
單克隆 (JL-1)
標(biāo)記
其他選擇 Biotin
FITC(2),HRP (1)
應(yīng)用范圍
其他選擇 Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA), Functional Studies (Func), Immunofluorescence (IF), Western Blotting (WB)
Western Blotting (WB)(11),Enzyme Immunoassay (EIA) (7),Immunoassay (IA) (5),Immunohistochemistry (Frozen Sections) (IHC (fro)) (5),Functional Studies (Func) (4),Immunofluorescence (IF) (3),Immunoprecipitation (IP) (3),ELISA (2),Immunodiffusion (ID) (2),Flow Cytometry (FACS) (1),Radioimmunoassay (RIA) (1)
[Pubmed] 3 references available
規(guī)格 50 μg
發(fā)貨至 中國(guó) (更改)
發(fā)貨時(shí)間 29至35個(gè)工作日

C1q A Subunit 抗體

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產(chǎn)品細(xì)節(jié)

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免疫原 Purified mouse C1q
克隆位點(diǎn) JL-1
亞型 IgG2b
特異性 The monoclonal antibody JL-1 recognizes the collagen-like region (CLR) of mouse C1q.
交叉反應(yīng) （詳細(xì)） Species reactivity (tested):Human, mouse, rat

目標(biāo)詳細(xì)情況

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目標(biāo)詳細(xì)情況

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背景 C1q is a 459 kDa molecule consisting of three individual polypeptide chains. The antibody has been generated by immunization of C1q-/- C57BL/6 mice with purified mouse C1q. C1q forms together with C1r and C1s the C1 macromolecule, the first component of the classical complement pathway. Interaction of immune complexes with C1q induces a conformational change within the C1 complex, which results in activation of the classical pathway. C1q functions as recognition unit by binding to the heavy chain of IgG or IgM (Fc gamma and Fc micro) provided that the immunoglobulins are bound to their antigen. Furthermore, C1q can also recognize molecular patterns associated with pathogens and it can bind to apoptotic blebs, where it activates the classical complement pathway and mediates phagocytosis. As such, C1q promotes the clearance of apoptotic cells and subsequent exposure of auto antigens, thereby preventing stimulation of the immune system. C1q is predominantly produced by macrophages but also by follicular dendritic cells, interdigitating cells and cells of the monocyte-macrophage lineage. C1q deficiency has a profound effect on host defence and clearance of immune complexes. Absence of C1q may cause autoimmunity by impairment of the clearance of apoptotic cells. Inherited C1q deficiency is also associated with the development of systemic lupus erythematosus (SLE).Synonyms: Complement 1q, Complement C1q, Complement C1q subcomponent subunit A
基因ID 712
NCBI Accession NP_057075
UniProt P02745
研究領(lǐng)域 Neurology, Innate Immunity, Complement Factors

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應(yīng)用備注 Optimal working dilution should be determined by the investigator.
限制 For Research Use only

貯存及處理

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貯存及處理

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濃度 0.1 mg/mL
緩沖液 PBS, 0.02?% sodium azide, 0.1?% bovine serum albumin
儲(chǔ)存液 Sodium azide
注意事項(xiàng) This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
儲(chǔ)存條件 4 °C

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