磷酸化嗜中性粒細胞胞漿因子1抗體

英文名稱 phospho-NCF1 (Ser359)
中文名稱 磷酸化嗜中性粒細胞胞漿因子1抗體
別    名 phospho-NCF1(Ser359); phospho-p47 phox(Ser359); NCF1 (phospho S359); 47 kDa autosomal chronic granulomatous disease protein; 47 kDa neutrophil oxidase factor; NADPH oxidase organizer 2; NCF 47K; Neutrophil cytosol factor 1; Neutrophil cytosolic factor 1; Neutrophil NADPH oxidase factor 1; Nox organizer 2; Nox organizing protein 2; NOXO2; p47 phox; p47phox; ;SH3 and PX domain containing protein 1A; SH3PXD1A; NADPH oxidase p47 phox; NCF1_HUMAN.
 
說 明 書 0.1ml  
產(chǎn)品類型 磷酸化抗體 
研究領(lǐng)域 腫瘤  細胞生物  信號轉(zhuǎn)導  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Rat, 
產(chǎn)品應用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 45kDa
細胞定位 細胞漿 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthesised phosphopeptide derived from human NCF1 around the phosphorylation site of Ser359
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
The heredity chronic granulomatous disease (CGF) has been linked to mutations in p47-phox and p67-phox. The cytosolic proteins p47-phox and p67-phox, also designated neutrophil cytosol factor (NCF)1 and NCF2, respectively, are required for activation of the superoxide-producing NADPH oxidase in neutrophils and other phagocytic cells. During activation of the NADPH oxidase, p47-phox and p67-phox migrate to the plasma membrane where they associate with cytochrome b558 and the small G protein Rac to form the functional enzyme complex. Both p47-phox and p67-phox contain two Src homology 3 (SH3) domains. The C-terminal SH3 domain of p67-phox has been shown to interact with the proline-rich domain of p47-phox, suggesting that p47-phox may faciliate the transport of p67-phox to the membrane.

Function:
NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production).xy-9387R    LRSAM1LRSAM1蛋白抗體
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xy-6546R    Lipophilin B親脂性蛋白B抗體
xy-6543R    LDOC1癌癥亮氨酸拉鏈下調(diào)因子1抗體
xy-6544R    LOXL2賴氨酰氧化酶相關(guān)蛋白2抗體
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xy-6249R    LCMT1亮氨酸羧基甲基轉(zhuǎn)移酶1抗體
xy-5937R    LETMD1宮頸癌原癌基因2抗體
xy-5790R    LOXL4賴氨酰氧化酶樣蛋白4抗體
xy-5810R    Lactoferrin乳鐵蛋白抗體
xy-7503R    Laminin 1+2層粘連蛋白1+2抗體
xy-6815R    LRRC15富含亮氨酸重復蛋白15抗體
xy-11530R    LAR受體蛋白酪氨酸磷酸酶F抗體
xy-13777R    Phospho-5-Lipoxygenase(Ser524)磷酸化5-脂氧合酶抗體
xy-2787R    LMP2低分子質(zhì)量蛋白2抗體
xy-2775R    LIMK1單絲氨酸蛋白激酶1抗體
xy-2796R    LMP7低分子量蛋白酶體7抗體
xy-0952R    LH促黃體生成素抗體
xy-4973R    Laminin alpha 1層粘蛋白α1抗體
xy-15591R    LETM1LETM1蛋白抗體
xy-1810R    LDHA乳酸脫氫酶抗體
xy-1532R    phospho-LKB1 (Thr363)磷酸化絲氨酸/蘇氨酸蛋白激酶抗體
xy-1526R    Laminin Beta 1層粘連蛋白β1抗體
xy-0976R    LPLUNC1鼻咽癌癌基因抗體
xy-1458R    LIFR白血病抑制因子受體抗體
xy-1839R    lamin A + C核纖層蛋白A抗體
xy-1840R    Lamin B核纖層蛋白B抗體(細胞核膜標志物)
xy-1841R    lamin A + C核纖層蛋白A/C抗體
xy-1845R    LRIG2LRIG2抗體
xy-1843R    LEF-1淋巴增強因子-1抗體
xy-1844R    LRIG1LRIG1抗體