細胞粘附分子伴侶蛋白1抗體

英文名稱 Sidekick 1
中文名稱 細胞粘附分子伴侶蛋白1抗體
別    名 FLJ31425; Protein sidekick-1; sdk1; SDK1_HUMAN; sidekick 1 antibody Sidekick homolog 1, cell adhesion molecule (chicken); sidekick1.

說 明 書 0.1ml  0.2ml  
研究領(lǐng)域 細胞生物  發(fā)育生物學(xué)  神經(jīng)生物學(xué)  細胞粘附分子  細胞膜蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Pig, Horse, Sheep, 
產(chǎn)品應(yīng)用 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 242kDa
細胞定位 細胞膜 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human Sidekick 1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
Cell adhesion molecules influence cell growth, differentiation, embryogenesis, immune response and cancer metastasis by networking information from the extracellular matrix to the cell. Sidekick-1 (SDK1) is a 2,213 amino acid single-pass membrane protein that functions as a cell adhesion molecule by guiding axonal terminals to specific synapses in developing neurons. Existing as three alternatively spliced isoforms, Sidekick-1 is expressed in retinal neurons and contains thirteen fibronectin type-III domains and six Ig-like C2-type (immunoglobulin-like) domains. Sidekick-1 expression is upregulated in glomeruli of patients with HIV-associated nephropathy, where it leads to podocyte dysfunction. The gene encoding Sidekick-1 maps to human chromosome 7p22.2 and murine chromosome 5 G2.

Function:
Cell adhesion protein that guides axonal terminals to specific synapses in developing neurons. Dysregulation of this protein may play an important role in podocyte dysfunction in HIV-associated nephropathy.

Subunit:
Contains 13 fibronectin type-III domains. Contains 6 Ig-like C2-type (immunoglobulin-like) domains.

Subcellular Location:
Membrane.xy-4919R    MSH3錯配修復(fù)蛋白3抗體
xy-11092R    MDGA2神經(jīng)元膜糖蛋白錨定蛋白2抗體
xy-11038R    MYRIPMYRIP蛋白抗體
xy-11093R    Myelin PLP髓磷酯髓鞘蛋白1抗體
xy-4910R    MCSF巨噬細胞克隆刺激因子抗體
xy-9338R    MARCH4膜相關(guān)環(huán)指蛋白4抗體
xy-4705R    MLCK肌球蛋白輕鏈激酶抗體
xy-7850R    MPS1單極紡錘體蛋白激酶1抗體
xy-7840R    Mad2L2有絲分裂阻滯缺陷2樣蛋白2抗體
xy-11297R    Monoamine Oxidase B單胺氧化酶B抗體
xy-11298R    MCM4微小染色體維持缺陷蛋白4抗體
xy-1534R    MAP1LC3A自噬微管相關(guān)蛋白輕鏈3抗體
xy-11191R    MRF/C11orf9髓鞘基因調(diào)控因子抗體
xy-11034R    MYBPC1肌球蛋白結(jié)合蛋白C抗體
xy-3678R    Phospho-MKP1 (Ser318)磷酸化絲裂原活化蛋白激酶磷酸酶1抗體
xy-1161R    Metabotropic glutamate receptor 2促代謝型谷氨酸受體2抗體
xy-1237R    MGLUR3代謝型谷氨酸受體-3抗體
xy-1162R    CXCL2巨噬細胞炎癥蛋白2（ GRＯβ）抗體
xy-1328R    Metallothionein金屬硫蛋白抗體
xy-3259R    Phospho-MAP2(Ser136)磷酸化微管相關(guān)蛋白2抗體
xy-9899R    MMRN1內(nèi)皮細胞MMRN1蛋白抗體
xy-3270R    Phospho-MEK1/2 (Ser218 + Ser222)磷酸化絲裂原活化蛋白激酶激酶1/2抗體
xy-3271R    Phospho-Met (c-Met) (Tyr1003)磷酸化肝細胞生長因子受體(原癌基因)抗體
xy-3272R    Phospho-Met (Tyr1234 + Tyr1235)磷酸化肝細胞生長因子受體(原癌基因)抗體
xy-3265R    Phospho-Mcl1 (Ser159 + Thr163)磷酸化髓樣細胞白血病-1抗體
xy-3266R    Phospho-MDM2 (Ser166)磷酸化雙微體2癌基因抗體
xy-3267R    Phospho-MEF2A (Thr312)磷酸化肌細胞增強因子2抗體
xy-3268R    Phospho-MEF2A (Ser408)磷酸化肌細胞增強因子2抗體
xy-3269R    phospho-MEK1 (Thr286)磷酸化絲裂原活化蛋白激酶激酶1抗體
xy-3260R    Phospho-MAP2 (Thr1620 + Thr1623)磷酸化微管相關(guān)蛋白2抗體
xy-2908R    MAPKAP Kinase 2絲裂原活化蛋白激酶活化的蛋白激酶2抗體
xy-3261R    Phospho-MAPKAPK2 (Thr222)磷酸化絲裂原活化蛋白激酶活化的蛋白激酶2抗體
xy-3262R    Phospho-MAPKAPK2(Thr334)磷酸化絲裂原活化蛋白激酶活化的蛋白激酶2抗體
xy-3263R    Phospho-MARCKS (Ser152 + Ser156)磷酸化丙氨酸蛋白激酶C底物Marcks抗體
xy-3359R    Phospho-MARCKS (Ser162)磷酸化丙氨酸蛋白激酶C底物Marcks抗體
xy-0668R    Met (c Met)肝細胞生長因子受體抗體
xy-6779R    phospho-MAP3K9+MAP3K10(Thr312 + Thr266)磷酸化絲裂原活化蛋白激酶3K9抗體