Smad核相互作用蛋白1抗體

英文名稱 SNIP1
中文名稱 Smad核相互作用蛋白1抗體
別    名 FHA domain-containing protein SNIP1; FLJ12553; Smad nuclear interacting protein (Smad nuclear interacting); Smad nuclear interacting protein; Smad nuclear-interacting protein 1; SNIP1 (Smad nuclear interacting protein); SNIP1; SNIP1_HUMAN; Splicing factor arginine/serine rich 4 (Pre mRNA splicing factor SRP75).

說 明 書 0.2ml  
研究領域 信號轉導  生長因子和激素  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, Sheep, 
產品應用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 46kDa
細胞定位 細胞核 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human SNIP1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產品介紹 background:
Members of the transforming growth factor-beta (TGF-Beta) superfamily play critical roles in controlling cell growth and differentiation. Effects of TGF-Beta family ligands are mediated by Smad proteins. The Smad nuclear interacting protein (SNIP1) contains a forkhead-associated (FHA) domain and acts as a nuclear inhibitor of CBP/p300. SNIP1 potently inhibits the activity of NF-kappa B, which binds the C/H1 domain of CBP/p300, by competing for the binding site. SNIP1 is also thought to induce expression of Cyclin D1 to promote cellular proliferation. SNIP1 is ubiquitously expressed with high expression in heart and skeletal muscle.

Function:
Down-regulates NF-kappa-B signaling by competing with RELA for CREBBP/EP300 binding. Involved in the microRNA (miRNA) biogenesis.

Subunit:
Binds SMAD4 and CREBBP/EP300. Binds the SMAD1/OAZ1/PSMB4 complex. Interacts with DROSHA and SMARCA4. Component of the SNARP complex which consists at least of SNIP1, SNW1, THRAP3, BCLAF1 and PNN. 

Subcellular Location:
Nucleus.xy-2013R    phospho-Nrf2 (Ser40)磷酸化核因子2相關因子2(Ser40)抗體
xy-10420R    Nemo-like kinaseNemo樣激酶抗體
xy-10421R    Phospho-Nemo-like kinase (Thr298)磷酸化Nemo樣激酶抗體
xy-10402R    phospho-NIFK (Thr238)磷酸化NIFK抗體
xy-10401R    phospho-NIFK (Thr230)磷酸化NIFK抗體
xy-13693R    NCKAP5NCKAP5蛋白抗體
xy-13694R    NOSTRIN一氧化氮合酶轉運誘導抗體
xy-13656R    NSMAF中性鞘磷脂相關因子抗體
xy-15592R    NFIL3人白介素3介導核因子抗體
xy-13657R    NSP3SH2結構域蛋白3A抗體
xy-2464R    Neuritin轉化神經突起蛋白抗體
xy-13765R    NPIP-like protein 1NPIP樣蛋白1抗體
xy-6058R    Nicastrin老年性癡呆蛋白APH2抗體
xy-6060R    NARC1神經細胞凋亡調節(jié)轉化蛋白1抗體（前蛋白轉化酶枯草溶菌素9）
xy-12018R    NPFF1 ReceptorG蛋白偶聯(lián)受體147抗體
xy-3513R    Nur77孤兒核受體蛋白Nur77抗體
xy-3313R    Phospho-Nur77(Ser351)磷酸化孤兒核受體蛋白Nur77抗體
xy-0452R    NAIF1 protein核凋亡誘導因子蛋白1
xy-1067R    NMDAR2C谷氨酸受體2C抗體
xy-0175R    TrkB酪氨酸激酶B抗體
xy-1091R    NADPH oxidase 4NADPH氧化酶4抗體
xy-9316R    NDE1核分布基因E同源蛋白1抗體
xy-9317R    NEK9絲氨酸/蘇氨酸蛋白激酶NEK9抗體
xy-9318R    phospho-NEK9(Thr210)磷酸化絲氨酸/蘇氨酸蛋白激酶NEK9抗體
xy-9319R    NNF1R多胺調控因子1抗體
xy-9300R    NNP1新型核蛋白質1抗體
xy-7080R    Nucleolar protein 3核仁蛋白3抗體
xy-9625R    NPAP1核孔蛋白1抗體
xy-4730R    NADPH oxidase 4NADPH氧化酶4抗體
xy-9713R    FAD24脂肪細胞分化因子24
xy-9468R    Nebulette肌動蛋白結合蛋白Z盤狀蛋白抗體
xy-9473R    NFAT5活化T細胞核因子5蛋白抗體
xy-9474R    phospho-NFAT5 (Ser1197)磷酸化活化T細胞核因子5蛋白抗體