抗藥蛋白抗體

英文名稱 Sorcin
中文名稱 抗藥蛋白抗體
別    名 22 kDa protein; Calcium binding protein amplified in mutlidrug resistant cells; CP 22; CP-22; CP22; SCN; Sorcin (class 4 gene); Sorcin; SORCN_HUMAN; SRI; V19.
  
說 明 書 0.1ml  0.2ml  
研究領(lǐng)域 心血管  結(jié)合蛋白  細(xì)胞骨架  細(xì)胞外基質(zhì)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 22kDa
細(xì)胞定位 細(xì)胞漿 細(xì)胞膜 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human SR1/Sorcin
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
Sorcin is a highly conserved protein, with 95% homology between hamster and human sorcin sequences. Sorcin has four putative Ca-binding domains, two of which exhibit strong homology to calmodulin “EF hand" motifs. Calcium binding directly to sorcin has been demonstrated by in vitro assays. Sorcin is closely related to members of calpain and sarcoplasmic Ca2+-binding protein subfamilies. Sorcin undergoes calcium-dependent translocation from the cytosol to cellular membranes. Sorcin binds to and modulates ryanodine receptors and is widely distributed including heart and brain tissues. At the subcellular level, sorcin localizes to T-tubule junctions of cardiac sarcoplasmic reticulum.

Function:
Calcium-binding protein that modulates excitation-contraction coupling in the heart. Contributes to calcium homeostasis in the heart sarcoplasmic reticulum. Modulates the activity of RYR2 calcium channels. 

Subunit:
Homodimer. Interacts with GCA, RYR2 and ANXA7.xy-4170R    TRIM25雌激素反應(yīng)鋅指蛋白抗體
xy-4173R    Twist2TWIST蛋白2抗體抗體
xy-5614R    phospho-TRIM25(The91)磷酸化雌激素反應(yīng)指狀蛋白抗體
xy-5605R    phospho-TERT(Ser1125)磷酸化端粒酶逆轉(zhuǎn)錄酶抗體
xy-5606R    phospho-TSC1(Thr417)磷酸化結(jié)節(jié)性硬化癥蛋白1抗體
xy-5608R    Phospho-TSC2(Ser540)磷酸化結(jié)節(jié)性硬化蛋白抗體
xy-5609R    Phospho-TSC2(Ser1420)磷酸化結(jié)節(jié)性硬化蛋白抗體
xy-5610R    Phospho-TSC2(Ser1798)磷酸化結(jié)節(jié)性硬化蛋白抗體
xy-5611R    Phospho-TSC2(Ser664)磷酸化結(jié)節(jié)性硬化蛋白抗體
xy-5612R    Phospho-TSC2(Ser1418)磷酸化結(jié)節(jié)性硬化蛋白抗體
xy-2941R    TNFR1腫瘤壞死因子受體1抗體
xy-6145R    TP53I13腫瘤蛋白p53誘導(dǎo)蛋白13(腫瘤抑制基因)
xy-3849R    TMEFF2增生性蛋白1抗體
xy-3870R    TMEM166跨膜蛋白166抗體
xy-3869R    TM9SF1跨膜蛋白超家族9-1抗體
xy-12308R    CD70腫瘤壞死因子配體超家族成員7抗體
xy-12321R    TCTN3結(jié)構(gòu)蛋白家族3抗體
xy-12328R    TCR alphaT淋巴細(xì)胞受體α抗體
xy-12329R    THEMIS選擇性胸腺細(xì)胞相關(guān)蛋白抗體
xy-12330R    Trim22環(huán)指蛋白94抗體
xy-10212R    Thrombomodulin血栓調(diào)節(jié)蛋白抗體
xy-12355R    TUG腺泡狀軟組織肉瘤結(jié)構(gòu)域蛋白ASPC抗體
xy-12343R    TRIB1G蛋白偶聯(lián)誘導(dǎo)蛋白2受體抗體
xy-10063R    Lymphotoxin Beta腫瘤壞死因子C/淋巴毒素β抗體
xy-7731R    TRIP1甲狀腺受體相互作用蛋白1抗體
xy-0086R    TGF beta 1轉(zhuǎn)化生長(zhǎng)因子β1/TGF β1/TGF-β1抗體
xy-6242R    TAAL6腫瘤相關(guān)抗原L6抗體
xy-11647R    TMEM59跨膜蛋白59抗體
xy-12041R    TAGLN3神經(jīng)元蛋白22抗體
xy-12042R    T2R60味覺受體蛋白家族2亞基60抗體