細胞周期G2/M期快速誘導蛋白SPDYA抗體

英文名稱 SPDYA
中文名稱 細胞周期G2/M期快速誘導蛋白SPDYA抗體
別    名 hSpy/Ringo A; Rapid inducer of G2/M progression in oocytes A; RINGO A; RINGO3; SPDY1; Speedy A; Speedy homolog 1 (Drosophila); Speedy homolog A; Speedy homolog A (Xenopus laevis); Speedy-1; SPY1; MGC110856; MGC57218; OTTHUMP00000082662; OTTHUMP00000082663; OTTHUMP00000082664.
 
說 明 書 0.2ml  
研究領域 細胞生物  細胞周期蛋白  激酶和磷酸酶  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, 
產品應用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 34kDa
細胞定位 細胞核 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human SPDYA
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產品介紹 background:
SPDYA (speedy homolog A (Drosophila)) regulates the G1/S phase transition of the cell cycle by binding and activating CDC2, CDK2 and CDKN1B/KIP1. SPDYA can activate CDK2 without promoting CDK2 phosphorylation. SPDYA mediates cell survival during the DNA damage process through activation of CDK2.

Function:
Regulates the G1/S phase transition of the cell cycle by binding and activating CDK1, CDK2 and CDKN1B/KIP1. Can activate CDK2 without promoting CDK2 phosphorylation. Mediates cell survival during the DNA damage process through activation of CDK2.

Subunit:
Interacts with CDK1, CDK2 and CDKN1B/KIP1. Found in a complex with both CDK2 and CDKN1B/KIP1.

Subcellular Location:
Nucleus.

Tissue Specificity:
Highly expressed in testis. Expressed at a low level in wide range of tissues including bone marrow, brain, heart, kidney, colon, liver, placenta, spleen, skeletal muscle, salivary gland, thyroid gland, thymus, trachea and uterus. Expressed at a slightly higher level in adrenal gland, cerebellum, small intestine, lung, prostate and trachea. Expression is cell cycle-dependent, being restricted to cells in G1/S phase.xy-1987R    MCP-3單核細胞趨化蛋白3抗體
xy-1989R    MIP4巨噬細胞炎癥蛋白18抗體
xy-1990R    MITFMITF相關轉錄因子抗體
xy-1992R    MTOR雷帕霉素靶蛋白抗體
xy-1993R    Muc2粘蛋白-2/上皮膜抗原2抗體
xy-1994R    Mucin 4粘蛋白4抗體
xy-0924R    Mafav-maf 肌腱膜纖維肉瘤癌基因同源物A抗體
xy-1344R    MMP-10基質金屬蛋白酶-10抗體
xy-0913R    Mtp53(N235K N239Y)突變型P53抗體
xy-0909R    Microsporidia protien蜜蜂微孢子蟲蛋白抗體
xy-1991R    MMP24基質金屬蛋白酶-24抗體
xy-4727R    Mannose Receptor巨噬細胞甘露糖受體抗體
xy-1022R    Mucin 5AC胃粘液素抗體
xy-0985R    MMP-20基質金屬蛋白酶20抗體
xy-0916R    Uromucoid尿調節(jié)蛋白抗體
xy-1400R    MEF2A肌細胞增強因子2抗體
xy-2442R    MyoD1/Myf3肌原調節(jié)蛋白抗體
xy-1155R    MASH1神經母細胞特異性轉移因子抗體
xy-4120R    MHC class I antigen B 15組織相關抗原HLA-B15抗體
xy-4054R    Methionine adenosyltransferase蛋氨酸腺苷轉移酶抗體
xy-5506R    phospho-MAPK11(Thr180+Tyr182)磷酸化絲裂原活化的蛋白激酶p38β抗體
xy-5507R    phospho-MAP1LC3A(Ser12)磷酸化自噬微管相關蛋白輕鏈3抗體
xy-2414R    MUC5B粘蛋白-5B抗體
xy-1525R    mucin3粘蛋白-3抗體
xy-10051R    Marek's Disease Vaccine, Live雞馬立克氏病火雞皰疹病毒抗體
xy-1468R    MDR1多藥耐藥蛋白/P-糖蛋白抗體(C端)
xy-2059R    Metronidazole甲硝唑抗體
xy-3645R    MAGE-A4黑色素瘤相關抗原4抗體
xy-3636R    CAB39鈣結合蛋白39抗體
xy-4053R    MAVS線粒體抗病毒信號MAVS蛋白抗體
xy-2755R    MCSF Receptor巨噬細胞集落刺激因子受體抗體
xy-1412R    MTA1腫瘤轉移相關蛋白1抗體