骨形態(tài)發(fā)生抑制蛋白SOST抗體

英文名稱 Sclerostin
中文名稱 骨形態(tài)發(fā)生抑制蛋白SOST抗體
別    名 BEER; Cortical hyperostosis with syndactyly; Sclerosteosis; Sclerostin; SOST; SOST_HUMAN; VBCH.
  
說 明 書 0.1ml  0.2ml  
研究領(lǐng)域 信號(hào)轉(zhuǎn)導(dǎo)  干細(xì)胞  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Dog, Pig, Horse, Rabbit, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 21kDa
細(xì)胞定位 分泌型蛋白 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human Sclerostin
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
Negative regulator of bone growth.Sclerostin (SOST) is a bone morphogenetic protein (BMP) antagonist, leading to the activation of BMP signaling. It negatively regulates the formation of bone by repressing the differentiation and/or function of osteoblasts induced by BMPs. It has been shown that Sclerostin binds BMP-5, -6, and -7 with high affinity and BMP-2 and -4 with low affinity. The noggin-sclerostin protein complex represents a novel mechanism for the fine-tuning of BMP activity in bone homeostasis. Evidence is accumulating that one of the important mechanisms of bone regulation by sclerostin is the modulation of Wnt/Beta-catenin signaling. Sclerostin also rapidly activated ERK-1/2 MAPK signaling, indicating the involvement of additional signaling pathways.

Function:
Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation.

Subunit:
Interacts with LRP4 (via the extracellular domain); the interaction facilitates the inhibition of Wnt signaling. Interacts with LRP5 (via the first two YWTD-EGF repeat domains); the interaction inhibits Wnt-mediated signaling. Interacts with LRP6xy-7674R    Porimin前細(xì)胞脹亡受體誘導(dǎo)膜損傷蛋白抗體
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xy-7109R    PARP4多腺苷二磷酸多聚酶4抗體/多聚ADP-核糖聚合酶4
xy-13767R    PABPC4L聚腺苷酸養(yǎng)結(jié)合蛋白4抗體
xy-0644R    PTP4A2肝再生磷酸酯酶2抗體
xy-9513R    Protein Z蛋白Z抗體
xy-9512R    Protein S蛋白S抗體
xy-6984R    PEBP2B多瘤病毒增強(qiáng)了結(jié)合蛋白２β抗體
xy-1325R    PDE4D磷酸二酯酶4D抗體
xy-1875R    Profilin 2前纖維蛋白2抗體
xy-1873R    PRCP脯氨酰羧肽酶抗體
xy-1857R    P2Y4P2Y4受體抗體
xy-1869R    PEA3瘤促活化因子3抗體
xy-1436R    PBP磷脂酰乙醇胺結(jié)合蛋白1抗體
xy-1527R    peripherin外周蛋白抗體
xym-1625M    PSA(Pa3)人前列腺特異性抗原單克隆抗體(包被)
xym-1626M    PSA (PA5)鼠抗人前列腺特異性抗原單克隆抗體(檢測(cè))
xy-1449R    Prohibitin抑制素/腫瘤抑制因子抗體
xy-1451R    PAFAH脂蛋白磷脂酶A2抗體
xy-0362R    Protein A重組金黃色葡萄球菌蛋白A抗體
xy-2395R    Pescadillo雌激素受體共調(diào)節(jié)因子抗體
xy-1518R    PersephinPSP抗體
xy-1515R    Pan-rasPan ras抗體
xy-1614R    PatchedPatched/PTCH抗體
xy-1880R    PTGEs前列腺素E合成酶抗體
xy-1832R    PPARGC1A過氧化物酶體增殖物激活受體γ輔激活子1α抗體
xy-3535R    PLK1絲氨酸/蘇氨酸蛋白激酶Plk1抗體
xy-3344R    Phospho-PLK1 (Thr210)磷酸化絲/蘇氨酸蛋白激酶Plk1抗體
xy-3536R    PPIG親環(huán)蛋白（親環(huán)素）PPIG抗體
xy-3461R    Phospho-PPIG (Ser376)磷酸化親環(huán)蛋白（親環(huán)素）PPIG抗體
xy-3346R    Phospho-PRAS40 (Thr246)磷酸化蛋白激酶AKT底物1抗體
xy-3347R    Phospho-PRK1(Thr774) + PRK2 (Thr816)磷酸化內(nèi)分泌腺衍生血管內(nèi)皮生長(zhǎng)因子抗體.