鱗狀細(xì)胞癌相關(guān)蛋白抗體

英文名稱 SCRO
中文名稱 鱗狀細(xì)胞癌相關(guān)蛋白抗體
別    名 DCN1 defective in cullin neddylation 1 domain containing 1; DCN1 like protein 1; DCUN1 domain containing protein 1; DCUN1L1; Defective in cullin neddylation protein 1 like protein 1; RP 42; RP42; RP42 homolog; SCCRO; SCRO; Squamous cell carcinoma related oncogene; Tes 3; Tes3.

說(shuō) 明 書 0.2ml  
研究領(lǐng)域 腫瘤  細(xì)胞生物  腫瘤細(xì)胞生物標(biāo)志物  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 29kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human SCRO/DCUN1D1
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
DCUN1D1 (DCUN1 domain-containing protein 1) contains a DUF298 domain and a UBA-like ubiquitin. Forms part of an E3 ubiquitin ligase complex for neddylation. Required for neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes by enhancing the rate of cullins neddylation. Functions to recruit the NEDD8-charged E2 enzyme to the cullin component. Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity. Acts also as an oncogene facilitating malignant transformation and carcinogenic progression. Defects in DCUN1D1 may be a cause of squamous cell carcinomas.
Strongly overexpressed in thyroid tumors, bronchioloalveolar carcinomas, and malignant tissues of squamous cell carcinoma of the oral tongue. Not overexpressed in aggressive adrenocortical carcinomas.

Subunit:
Part of an E3 complex for neddylation composed of cullins, RBX1, UBE2M and CAND1. Interacts (via the C-terminus 50 AA) with CUL1, CUL2, CUL3, CUL4 and CUL5. Binds neddylated CUL1. Interacts (via the C-terminus 50 AA) directly with RBX1. Interacts preferentially with UBE2M-NEDD8 thioester (via N-terminus 1-26 AA) than with free UBE2M. Interacts with CAND1 when in complex with CUL1-RBX1.xy-2311M    Classical swine fever virus, CSFV豬瘟病毒抗體
xy-2283R    EMC1腺樣癌特異性相關(guān)抗原EMC1抗體
xy-3966R    PPM2C蛋白磷酸酶2C抗體
xy-9393R    CAF1p55染色質(zhì)組裝因子1P55抗體
xy-8458R    PTRFRNA聚合酶1和轉(zhuǎn)錄釋放因子抗體
xy-8866R    PISD磷脂酰絲氨酸脫羧酶PISD抗體
xy-3742R    PNPLA1含patatin樣磷脂酶1抗體
xy-3698R    PML早幼粒細(xì)胞白血病蛋白抗體
xy-2265R    Peptide YY/PYY酪酪肽抗體
xy-9289R    PACRG麻瘋病和帕金森氏病共同調(diào)節(jié)蛋白抗體
xy-9290R    RNF131環(huán)指蛋白131抗體
xy-3807R    Phospholipase A2 activator protein磷脂酶A2激活蛋白抗體
xy-3809R    thymidine phosphorylase胸苷磷酸化酶抗體
xy-3817R    Piwil2piwi樣2蛋白抗體
xy-3815R    presenilin 2早老素蛋白-2抗體
xy-8176R    PHF8組蛋白賴氨酸去甲基化酶PHF8抗體
xy-9363R    TRAP2腫瘤壞死因子受體相關(guān)蛋白2抗體
xy-9366R    PSMD7蛋白酶調(diào)解因子7抗體
xy-2215R    phosphos-PCNA (Tyr211)磷酸化增殖細(xì)胞核抗原抗體
xy-3027R    phospho-AMPK beta 1 (Ser182)磷酸化腺苷單磷酸活化蛋白激酶β1抗體
xy-4033R    PDHB丙酮酸脫氫酶E1β亞單位抗體
xy-4032R    PHKB磷酸化酶β抗體
xy-4030R    Pancreatic Amylase胰淀粉酶抗體
xy-4034R    PDHA1丙酮酸脫氫酶α1抗體
xy-4036R    phospho-PDHA1(Ser293)磷酸化丙酮酸脫氫酶α1抗體
xy-2739R    PDPK13磷酸肌醇依賴性蛋白激酶1抗體
xy-3017R    Phospho-PDPK1(Tyr373 + Tyr376)磷酸化3磷酸肌醇依賴性蛋白激酶1抗體
xy-2740R    p53BP1p53結(jié)合蛋白1抗體
xy-3726R    phospho-PKC delta (Tyr52)磷酸化蛋白激酶C亞性D型抗體
xy-3727R    phospho-PKC delta (Thr505/507)磷酸化蛋白激酶C亞性D型抗體