糖皮質(zhì)激素調(diào)節(jié)激酶1抗體

英文名稱 SGK1
中文名稱 糖皮質(zhì)激素調(diào)節(jié)激酶1抗體
別    名 Serum/glucocorticoid regulated kinase 1; SGK 1; SGK-1; Serine/threonine protein kinase SGK; Serine/threonine protein kinase Sgk1; Serum and glucocorticoid regulated kinase; Serum/glucocorticoid regulated kinase; SGK 1; SGK; SGK1_HUMAN.
 
說(shuō) 明 書 0.1ml  0.2ml  
研究領(lǐng)域 腫瘤  細(xì)胞生物  免疫學(xué)  神經(jīng)生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  生長(zhǎng)因子和激素  轉(zhuǎn)錄調(diào)節(jié)因子  激酶和磷酸酶  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Dog, Cow, Horse, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 49kDa
細(xì)胞定位 細(xì)胞核 細(xì)胞漿 細(xì)胞膜 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human SGK1
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
SGK1 is a protein kinase that plays an important role in cellular stress response. SGK1 activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. Sustained high levels of SGK1 and activity may contribute to conditions such as hypertension and diabetic nephropathy. This protein also mediates cell survival signals, as it has been shown to phosphorylate and negatively regulate the pro apoptotic FOXO3A protein. Ser 422 is a critical site on the protein and may be involved in its activation.

Function:
Protein kinase that plays an important role in cellular stress response. Activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability and renal sodium excretion. Sustained high levels and activity may contribute to conditions such as hypertension and diabetic nephropathy. Mediates cell survival signals, phosphorylates and negatively regulates pro-apoptotic FOXO3A. Phosphorylates NEDD4L, which leads to its inactivation and to the subsequent activation of various channels and transporters such as ENaC, KCNA3/Kv1.3 or EAAT1. Isoform 2 exhibited a greater effect on cell plasma membrane expression of ENaC and Na(+) transport than isoform 1.xy-5477R    phospho-p38 MAPK (Tyr323)磷酸化p38MAPK抗體
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xy-5487R    phospho-MAPK8 ( Thr183 + Tyr185)磷酸化氨基末端激酶2抗體
xy-12201R    MELK蛋白激酶MPK38抗體
xy-12206R    MGST1微粒體谷胱甘肽S轉(zhuǎn)移酶1抗體
xy-10074R    MUC13粘蛋白13抗體
xy-8689R    MEPE細(xì)胞外基質(zhì)磷酸化抗體
xy-2725R    Mast Cell Tryptase肥大細(xì)胞蛋白酶7抗體
xy-4128R    MAP4微管相關(guān)蛋白4抗體
xy-5120R    MSS126S蛋白酶調(diào)節(jié)亞型7抗體
xy-3629R    MEG1蛋白酪氨酸磷酸酶非受體型4抗體
xy-13355R    MBOAT4腦腸肽O?；D(zhuǎn)移酶抗體
xy-5272R    MRG15轉(zhuǎn)錄調(diào)控因子MRG15抗體
xy-5273R    MLL5髓系/淋巴混合譜系白血病蛋白5抗體
xy-4835R    MPV17T淋巴細(xì)胞成熟相關(guān)蛋白抗體
xy-9961R    cblA甲基丙二酸尿癥cblA抗體
xy-8564R    non-muscle Myosin IIA非平滑肌肌球蛋白2A抗體
xy-8671R    MMS19DNA修復(fù)甲基磺酸敏感性基因19抗體
xy-9680R    C19orf2819號(hào)染色體開放閱讀框28抗體
xy-3802R    Mammaglobin A乳腺珠蛋白1抗體
xy-3805R    Myoglobin肌紅蛋白抗體
xy-3804R    MSH6錯(cuò)配修復(fù)蛋白6抗體
xy-3803R    Mammaglobin B乳腺珠蛋白2抗體
xy-6387R    MEI-1減數(shù)分裂缺陷蛋白1抗體
xy-7630R    MTCH1細(xì)胞增殖誘導(dǎo)蛋白60（早老素相關(guān)蛋白）
xy-7631R    MTCH2線粒體載體同源蛋白2抗體
xy-7632R    MTFR1線粒體裂變調(diào)節(jié)蛋白1抗體
xy-7633R    MTP18線粒體蛋白18抗體
xy-7629R    MICS1生長(zhǎng)激素誘導(dǎo)跨膜蛋白抗體（真皮乳頭源性蛋白2）
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xy-11417R    MC4 Receptor黑素皮質(zhì)素4受體抗體
xy-11418R    MC5 Receptor黑素皮質(zhì)素受體5抗體
xy-11434R    MOT8甲狀腺激素轉(zhuǎn)運(yùn)蛋白/單羧酸轉(zhuǎn)運(yùn)蛋白7/8抗體