信號(hào)轉(zhuǎn)導(dǎo)和轉(zhuǎn)錄激活因子6抗體

英文名稱 STAT6
中文名稱 信號(hào)轉(zhuǎn)導(dǎo)和轉(zhuǎn)錄激活因子6抗體
別    名 signal transducers and activators of transduction 6; D12S1644; IL 4 STAT; IL4 STAT; Interleukin 4 Induced; Interleukin 4 Induced Transcription Factor IL4 STAT; Signal Transducer And Activator Of Transcription 6 Interleukin 4 Induced; Signal Transducer And Activator Of Transcription 6 Nirs Variant 1; STAT 6; STAT interleukin4 induced; STAT6B; STAT6C; Transcription factor IL 4 STAT.

說(shuō) 明 書(shū) 0.1ml  0.2ml  
研究領(lǐng)域 腫瘤  發(fā)育生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  細(xì)胞凋亡  轉(zhuǎn)錄調(diào)節(jié)因子  表觀遺傳學(xué)  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 94kDa
細(xì)胞定位 細(xì)胞核 細(xì)胞漿 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human STAT6
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X (L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins.

Function:
Carries out a dual function: signal transduction and activation of transcription. Involved in interleukin-4 signalling.

Subunit:
Forms a homodimer or a heterodimer with a related family member. Interacts with NCOA1 via its C-terminal LXXLL motif.xy-11273R    REAB淋巴細(xì)胞受體相關(guān)蛋白抗體
xy-3023R    phospho-RUNX1 (Ser249)磷酸化急性髓細(xì)胞白血病1蛋白抗體
xy-3551R    RIPK3受體結(jié)合絲氨酸蘇氨酸激酶3抗體
xym-0855M    Insulin (1G11)胰島素單克隆抗體
xy-3558R    phospho-Rb (Ser249)磷酸化視網(wǎng)膜母細(xì)胞瘤相關(guān)蛋白1抗體
xy-3378R    Phospho-Rb (Ser608)磷酸化視網(wǎng)膜母細(xì)胞瘤相關(guān)蛋白1抗體
xy-9452R    RGS4精神分裂癥相關(guān)蛋白9抗體
xy-6391R    RPRD1A細(xì)胞周期依賴性激酶抑制相關(guān)蛋白抗體
xy-7682R    RBM38RNA結(jié)合蛋白38抗體
xy-7692R    Relaxin 1松弛肽/松弛素抗體
xy-7693R    Renalase腎胺酶抗體
xy-9243R    RNF20環(huán)指蛋白20抗體
xy-9322R    RanBP1RAN結(jié)合蛋白1抗體
xy-3791R    RAE1mRNA結(jié)合蛋白抗體
xy-2125R    RNF126環(huán)指蛋白126抗體
xym-2025M    RBC(G2H4)小鼠抗人紅細(xì)胞單克隆抗體
xy-1501R    TIG2視黃酸受體應(yīng)答蛋白2抗體
xy-1504R    RAP1A抗Rap1A抗體
xy-6703R    RAB7RAS癌基因相關(guān)蛋白R(shí)AB7抗體
xy-7827R    RCLc-Myc應(yīng)答蛋白抗體
xy-8307R    RAB6BRAS癌基因相關(guān)蛋白R(shí)AB6B抗體
xy-7826R    RABGAP1Rab蛋白GTP酶激活蛋白1抗體
xy-5774R    RELM beta結(jié)腸癌相關(guān)基因蛋白抗體（resistin-like β）
xy-5490R    phospho-Ron(Tyr1238)磷酸化原癌基因c-Met相關(guān)酪氨酸激酶抗體
xy-9172R    RNF6環(huán)指蛋白6抗體
xy-5972R    Ribonuclease 6核糖核酸酶6抗體
xy-5683R    Phospho-RASGRF1 (Ser929)磷酸化Ras特異性鳥(niǎo)嘌呤核苷酸釋放因子1
xy-5657R    phospho-RAD9(Ser380)磷酸化細(xì)胞周期檢查控制蛋白質(zhì)抗體
xy-5658R    phospho-RAD9(Ser387)磷酸化細(xì)胞周期檢查控制蛋白質(zhì)抗體
xy-5659R    phospho-RAD9(Tyr28)磷酸化細(xì)胞周期檢查控制蛋白質(zhì)抗體
xy-5645R    phospho-c-Raf(Ser301)磷酸化原癌基因c-Raf抗體
xy-5647R    phospho-c-Raf(Ser494)磷酸化原癌基因c-Raf抗體
xy-5648R    phospho-c-Raf(Ser43)磷酸化原癌基因c-Raf抗體
xy-5649R    phospho-c-Raf(Ser471)磷酸化原癌基因c-Raf抗體
xy-5650R    phospho-c-Raf(Tyr341)磷酸化原癌基因c-Raf抗體