細胞因子信號傳導抑制蛋白2抗體

英文名稱 Socs 2
中文名稱 細胞因子信號傳導抑制蛋白2抗體
別    名 suppressor of cytokine signaling 2; suppressor of cytokine signaling SOCS2; CIS2; Cish2; SSI-2; SOCS2; STATI2; SOCS2_HUMAN.
  
說 明 書 0.1ml  0.2ml  
研究領域 細胞生物  免疫學  神經(jīng)生物學  信號轉(zhuǎn)導  細胞凋亡  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse, Rat, Dog, Pig, Cow, Horse, 
產(chǎn)品應用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 23kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human Socs 2
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
This gene encodes a member of the suppressor of cytokine signaling (SOCS) family. SOCS family members are cytokine-inducible negative regulators of cytokine receptor signaling via the Janus kinase/signal transducer and activation of transcription pathway (the JAK/STAT pathway). SOCS family proteins interact with major molecules of signaling complexes to block further signal transduction, in part, by proteasomal depletion of receptors or signal-transducing proteins via ubiquitination. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10, interferon (IFN)-gamma and by cytokine receptors such as growth horomone receptor. The protein encoded by this gene interacts with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R) and is thought to be involved in the regulation of IGF1R mediated cell signaling. This gene has pseudogenes on chromosomes 20 and 22. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

Function:
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.xy-7709R    Retinoic acid induced 17維甲酸誘導蛋白17抗體
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xy-11620R    RGS21G蛋白信號調(diào)節(jié)蛋白21抗體
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xy-8333R    RDH13視黃醇脫氫酶13抗體
xy-8391R    RNF75環(huán)指蛋白75抗體
xy-8392R    RIT1RIT1蛋白抗體
xy-9246R    RNF19B環(huán)指蛋白19B抗體
xy-8509R    Reg3a胰島β細胞生長因子抗體
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xy-9233R    RNF180環(huán)指蛋白180抗體
xy-9249R    RNF123環(huán)指蛋白123抗體
xy-8499R    RED軟骨肉瘤相關蛋白2抗體
xy-8494R    RNF210環(huán)指蛋白210抗體
xy-9238R    RNF23環(huán)指蛋白23抗體
xy-9239R    RNF24環(huán)指蛋白24抗體
xy-9240R    RNF25環(huán)指蛋白25抗體