富含半胱氨酸的酸性分泌蛋白抗體

英文名稱 SPARC
中文名稱 富含半胱氨酸的酸性分泌蛋白抗體
別    名 AA517111; Basement membrane protein 40; BM 40; BM40; Cysteine rich protein; hm:zeh0062; MGC128090; ON; Osteonectin; Secreted acidic cystein rich glycoprotein; Secreted protein acidic and rich in cysteine; Secreted protein acidic cysteine rich (osteonectin); Secreted protein acidic cysteine rich; SPRC; SPRC_HUMAN.

說 明 書 0.1ml  0.2ml  
研究領(lǐng)域 腫瘤  細(xì)胞生物  信號(hào)轉(zhuǎn)導(dǎo)  干細(xì)胞  細(xì)胞周期蛋白  細(xì)胞骨架  細(xì)胞外基質(zhì)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 33kDa
細(xì)胞定位 細(xì)胞膜 細(xì)胞外基質(zhì) 分泌型蛋白 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human SPARC
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
This gene encodes a cysteine-rich acidic matrix-associated protein. The encoded protein is required for the collagen in bone to become calcified but is also involved in extracellular matrix synthesis and promotion of changes to cell shape. The gene product has been associated with tumor suppression but has also been correlated with metastasis based on changes to cell shape which can promote tumor cell invasion. [provided by RefSeq, Dec 2011].

Function:
Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.

Subcellular Location:
Secreted, extracellular space, extracellular matrix, basement membrane. Note=In or around the basement membrane.xy-9051R    TRPM4瞬時(shí)受體電位離子通道蛋白4抗體（M亞家族）
xy-11309R    TSARG2精子形成相關(guān)凋亡蛋白2抗體
xy-9009R    Transportin 1轉(zhuǎn)運(yùn)蛋白1抗體
xy-7103R    THAP1核凋亡因子THAP1抗體
xy-7105R    TIA1細(xì)胞毒顆粒相關(guān)蛋白TIA-1抗體
xy-7104R    THYN1胸腺細(xì)胞核蛋白1抗體
xy-7551R    TNFAIP3 interacting protein 3腫瘤壞死因子α誘導(dǎo)相互作用蛋白3抗體
xy-12097R    TRPV3辣椒素受體3抗體
xy-12105R    TEX261TEX261蛋白抗體
xy-2087R    TSHR促甲狀腺素受體抗體
xy-3457R    Phospho-TrkA(Tyr674 + Tyr675) + TrkB(Tyr706 + Tyr707)磷酸化酪氨酸激酶A抗體
xy-1444R    TLR3Toll樣受體3抗體
xy-1450R    TCRGT細(xì)胞受體γ抗體
xy-4514R    Transketolase (CT)轉(zhuǎn)酮醇酶(轉(zhuǎn)羥乙醛酶)抗體（C端）
xy-1215R    TPH色氨酸羥化酶抗體
xy-1214R    TRAIL腫瘤壞死因子相關(guān)凋亡誘導(dǎo)配體抗體
xy-0152R    Prealbumin轉(zhuǎn)甲狀腺素蛋白/前白蛋白抗體
xy-1151R    TRF1端粒體復(fù)制結(jié)合因子1抗體
xy-0193R    TrkA酪氨酸激酶A抗體
xy-1212R    TRAF1腫瘤壞死因子受體相關(guān)因子1抗體
xy-1213R    TRAF2 腫瘤壞死因子受體相關(guān)因子2抗體
xy-0157R    Tau protein微管相關(guān)蛋白抗體
xy-0822R    TARDBPTar DNA 結(jié)合蛋白43抗體
xy-1039R    Tenascin C細(xì)胞粘合素(固生蛋白)抗體
xy-0535R    TFF3三葉肽因子3抗體
xy-1144R    TFPI-2組織因子途徑抑制劑-2抗體
xy-0066R    TGF alpha轉(zhuǎn)移生長因子α抗體(TGFα)
xy-0103R    TGF Beta 1轉(zhuǎn)化生長因子β1抗體（TGFβ1）
xy-0100R    TGF beta 2 Propeptide轉(zhuǎn)移生長因子β2抗體（TGFβ2）
xy-0099R    TGF beta 3 propeptide轉(zhuǎn)移生長因子β3抗體（TGFβ3）
xy-0117R    TGF beta Receptor II轉(zhuǎn)移生長因子β受體2抗體（TGF-βRⅡ，TGFβRⅡ）
xy-0638R    TGF beta Receptor I轉(zhuǎn)移生長因子β受體1抗體