核轉(zhuǎn)錄調(diào)節(jié)因子YY1抗體

英文名稱 YY1
中文名稱 核轉(zhuǎn)錄調(diào)節(jié)因子YY1抗體
別    名 Yin Yang 1; YY1 transcription factor; CF1; Delta; Delta transcription factor; NF E1; NFE1; Transcriptional repressor protein YY1; UCR motif DNA binding protein; UCRBP; Yin and yang 1; Yin Yang 1; Ying Yang 1; YY 1; YY 1 transcription factor; TYY1_HUMAN.

說(shuō) 明 書 0.2ml  
研究領(lǐng)域 細(xì)胞生物  免疫學(xué)  染色質(zhì)和核信號(hào)  轉(zhuǎn)錄調(diào)節(jié)因子  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 46kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human YY1
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

產(chǎn)品介紹 background:
YY1 is a ubiquitously distributed transcription factor belonging to the GLI Kruppel class of zinc finger proteins. The protein is involved in repressing and activating a diverse number of promoters. YY1 may direct histone deacetylases and histone acetyltransferases to a promoter in order to activate or repress the promoter, thus implicating histone modification in the function of YY1.

Function:
Multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site. Binds to the consensus sequence 5'-CCGCCATNTT-3'; some genes have been shown to contain a longer binding motif allowing enhanced binding; the initial CG dinucleotide can be methylated greatly reducing the binding affinity. The effect on transcription regulation is depending upon the context in which it binds and diverse mechanisms of action include direct activation or repression, indirect activation or repression via cofactor recruitment, or activation or repression by disruption of binding sites or conformational DNA changes. Its activity is regulated by transcription factors and cytoplasmic proteins that have been shown to abrogate or compley inhibit YY1-mediated activation or repression. For example, it acts as a repressor in absence of adenovirus E1A protein but as an activator in its presence. May play an important role in development and differentiation. Proposed to recruit the PRC2/EED-EZH2 complex to target genes that are transcriptional repressed. Involved in DNA repair. In vitro, binds to DNA recombination intermediate structures (Holliday junctions). 
Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair; proposed to target the INO80 complex to YY1-responsive elements. xy-2494R    Kif14 protein驅(qū)動(dòng)蛋白家族Member14蛋白抗體
xy-2130R    Ki-67Ki67蛋白抗體
xy-2424R    KCNH1鉀離子通道蛋白EAG1抗體
xy-1395R    KLF6轉(zhuǎn)染抑癌基因KLF6抗體
xy-3649R    KLF8KLF樣轉(zhuǎn)錄因子8抗體
xy-3648R    KEAP1胞質(zhì)接頭蛋白Keap1抗體
xy-2303R    phospho-KLF5(Ser311)磷酸化腸道內(nèi)富含的Kruppel樣因子5抗體
xy-10495R    KMT6 (phospho Ser21)磷酸化抑癌蛋白EZH2抗體
xy-2231R    LYRICAEG-1抗體
xy-6309R    IL-6白介素6抗體
xy-2200R    LDL低密度脂蛋白抗體
xy-12310R    LRRC19LRRC19蛋白抗體
xym-4577M    LAMR1(M1S3)層粘連蛋白受體1單克隆抗體
xym-0940M    LAMR1(5D4)層粘連蛋白受體1單克隆抗體
xy-10126R    LATT細(xì)胞活化連接蛋白抗體
xy-2657R    LIX1LIX1抗體
xy-2044R    LOX 1凝集素樣氧化型低密度脂蛋白受體抗體
xy-2661R    MD1MD-1蛋白抗體
xy-2662R    MD-2MD-2蛋白抗體
xy-1311R    LYVE-1淋巴管內(nèi)皮透明質(zhì)酸受體抗體
xy-0897R    liver FABP肝臟型脂肪酸結(jié)合蛋白抗體
xy-8539R    Luciferase熒光素酶抗體
xy-7687R    LAP3亮氨酸氨基肽酶3抗體
xy-0824R    LFABP/FABP-1肝臟型脂肪酸結(jié)合蛋白抗體
xy-8527R    LPP2腫瘤抑制基因LPP2抗體
xy-2904R    LATS1腫瘤抑制基因LATS1抗體
xy-3247R    Phospho-LIMK1(Thr508) + LIMK2(Thr505)磷酸化單絲氨酸蛋白激酶1/2抗體
xy-3246R    Phospho-LATS1 (Ser909)磷酸化腫瘤抑制基因LATS1抗體
xy-3248R    phospho-LKB1(Ser334)磷酸化絲氨酸/蘇氨酸蛋白激酶抗體
xy-3249R    phospho-LKB1(Ser428)磷酸化絲氨酸/蘇氨酸蛋白激酶抗體
xy-3250R    Phospho-LKB1(Thr189)磷酸化絲氨酸/蘇氨酸蛋白激酶抗體
xy-0456R    GNRH黃體激素釋放激素類似物抗體
xy-3254R    Phospho-Lamin A + C(Ser22)磷酸化核纖層蛋白A/C抗體
xy-3255R    Phospho-Lck (Tyr505)磷酸化淋巴細(xì)胞特異性蛋白酪氨酸激酶抗體
xy-2906R    Lyn膜相關(guān)蛋白酪氨酸激酶Lyn抗體