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當(dāng)前位置:上海信裕生物科技有限公司>>抗體>>一抗>> WW結(jié)構(gòu)域E3泛素連接酶1抗體
產(chǎn)品型號
品 牌Abcam
廠商性質(zhì)生產(chǎn)商
所 在 地上海
更新時(shí)間:2015-06-05 14:57:26瀏覽次數(shù):316次
聯(lián)系我時(shí),請告知來自 化工儀器網(wǎng)WW結(jié)構(gòu)域E3泛素連接酶1抗體
英文名稱 WWP1
中文名稱 WW結(jié)構(gòu)域E3泛素連接酶1抗體
別 名 AIP 5; AIP5; Atropin-1-interacting protein 5; hSDRP1; nedd4 like; NEDD4-like E3 ubiquitin-protein ligase WWP1; Tiul1; WW domain containing E3 ubiquitin protein ligase 1; WW domain-containing protein 1; WWP 1; WWP1_HUMAN.
說 明 書 0.2ml
研究領(lǐng)域 腫瘤 細(xì)胞生物 信號轉(zhuǎn)導(dǎo) 腫瘤細(xì)胞生物標(biāo)志物
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep,
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (石蠟切片需做抗原修復(fù))
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 105kDa
細(xì)胞定位 細(xì)胞核 細(xì)胞漿 細(xì)胞膜
性 狀 Lyophilized or Liquid
濃 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human WWP1
亞 型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed PubMed
產(chǎn)品介紹 background:
WWP1 is an E3 ubiquitin ligase and belongs to a family of NEDD4-like proteins. WWP1 contains 4 tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. The HECT domain of WWP1 has been implicated in regulating the localization and stability of p53 – inhibition of WWP1 results in a decrease in p53 expression, whilst WWP1 mediated stabilization of p53 appears to be associated with an accumulation of cytoplasmic p53. WWP1 also negatively regulates the TGF beta tumor suppressor pathway by inactivating its molecular components (SMAD2, SMAD4 and TGFbetaR1). WWP1 has been implicated in both breast and prostate cancers.
Function:
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotes degradation of SMAD2 in response to TGF-beta signaling, which requires interaction with TGIF.xy-0490R PPP4C磷酸酯酶-2Ac抗體
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xy-0250R PPAR delta + betaD型-過氧化酶活化增生受體抗體
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xy-0111R progesterone receptor孕激素受體抗體
xy-0532R PHD3脯氨酸羥化酶抗體
xy-0024R presenilin 1早老素蛋白-1抗體
xy-0025M presenilin 1早老素蛋白-1抗體
xy-0024M presenilin 1早老素蛋白-1抗體
xy-0669R PSCA前列腺干細(xì)胞抗原抗體
xy-0179R PSD95突觸后密度蛋白95抗體
xy-0561R P-selectin/CD62pP選擇素抗體
xy-0748R PTEN一種腫瘤抑制基因抗體(N端)
xy-1115R AMPK alpha-1腺苷單磷酸活化蛋白激酶α1/AMPK α 1抗體
xy-0040R protein C維生素K依賴的蛋白C重鏈抗體
xy-2692R Plexin A1神經(jīng)叢蛋白A1抗體
xy-3517R PAK4p21激活激酶4抗體
xy-3314R Phospho-PAK4(Ser474) + PAK5(Ser602) + PAK6(Ser560)磷酸化p21激活激酶4/5/6抗體
xy-3315R Phospho-PAK1(Ser199 + Ser204) + PAK2 (Ser192 + Ser197)磷酸化p21激活激酶1/2抗體
xy-3316R Phospho-PAK1 + PAK2 + PAK3 (T423 + T402 + T421)磷酸化p21激活激酶1/2抗體
xy-3317R Phospho-PAK2 (Ser20)磷酸化p21激活激酶2抗體
xy-3532R PLCG 2磷酯酶Cγ2抗體
xy-3318R Phospho-PDGFRA(Tyr1018)磷酸化血小板源性生長因子受體-α抗體
xy-3319R Phospho-PDGFRA(Tyr754)磷酸化血小板源性生長因子受體-α抗體
xy-1346R P73 proteinP73腫瘤抑制基因抗體
xy-4958R PCGF1表觀抑制因子Polycomb家族成員PCGFl蛋白抗體
xy-12070R P2Y10G蛋白偶聯(lián)嘌呤受體p2y10抗體
xy-0190R PACAP-27/38腺苷酸環(huán)化酶激活肽-27/38抗體
xy-0534R p19ARFp19ARF抑癌基因抗體
xy-0741R CDKN1Ap21蛋白抗體
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