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當(dāng)前位置:凱立德生物醫(yī)藥技術(shù)(上海)有限公司>>信號(hào)通路研究>> 7-乙基-10-羥基喜樹堿7-Ethyl-10-Hydroxycamptothecin(SN-38)

7-乙基-10-羥基喜樹堿7-Ethyl-10-Hydroxycamptothecin(SN-38)

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更新時(shí)間:2016-08-18 23:37:41瀏覽次數(shù):1491次

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Product Name: 7-乙基-10-羥基喜樹堿7-Ethyl-10-Hydroxycamptothecin(SN-38)
CAS No.: 86639-52-3
Appearance: White to light yellow crystalline powder
Assay (On dried basis):>99%

Product Name: 7-Ethyl-10-Hydroxycamptothecin(SN-38); SN 38   7-乙基-10-羥基喜樹堿
CAS No.: 86639-52-3
Chemical Name: (4S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizi,2-b]quinoline-3,14(4H,12H)dione
Molecular formula: C22H20N2O5
Molecular weight: 392.40
Physical and chemical properties: 7-Ethyl-10-Hydroxycamptothecin is pale yellow to yellow crystalline powder, soluble in DSMO, methanol and ethanol. Not soluble in water and chloroform.
Strorage: Store in a cool and dry area, sealed and keep from direct light
Indication: It can be used in the treatment for non-small-cell lung cancer, rectum cancer and also can be used as the intermediates of Irinotecan

Appearance: White to light yellow crystalline powder
Assay (On dried basis):>99%    

Usage: Irinotecan Intermediate; A metabolite of Irinotecan, a DNA topoisomerase inhibitor.

Biological Activity: Active metabolite of CPT-11  that inhibits DNA topoisomerase I (IC50 values are 0.74 and 1.9 μM in P388 and Ehrlich cells respectively). Inhibits DNA and RNA synthesis (IC50 values are 0.077 and 1.3 μM respectively) but does not affect protein synthesis. Displays potent antitumor activity against a range of human tumor cell lines (IC50 values are 3.3, 13, 19 and 22 nM for HCT-116, BEL-7402, HL60 and HELA cells respectively).    

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