欧美……一区二区三区,欧美日韩亚洲另类视频,亚洲国产欧美日韩中字,日本一区二区三区dvd视频在线

凱立德生物醫(yī)藥技術(上海)有限公司
中級會員 | 第2年

021-58180488

當前位置:> 供求商機> 佛司可林Forskolin(Colforsin)

佛司可林Forskolin(Colforsin)
  • 佛司可林Forskolin(Colforsin)
舉報

貨物所在地:上海上海市

地: 國產

更新時間:2024-06-12 21:00:07

瀏覽次數(shù):104

在線詢價收藏商機

( 聯(lián)系我們,請說明是在 化工儀器網 上看到的信息,謝謝!)

Forskolin(Colforsin) CAS:66575-29-9 佛司可林Forskolin(Colforsin)
Appearance:Off-white to white powder
Assay(HPLC):>98%

Forskolin(Colforsin) CAS:66575-29-9  佛司可林Forskolin(Colforsin) 

Appearance:Off-white to white powder

Assay(HPLC):>98%

Product Name: Forskolin

CAS No.: 66575-29-9

Synonyms: Colforsin; ForsLean; Coleonol; HL 362; L 75-1362B; NSC 357088; NSC 375489; 7β-Acetoxy-8,13-epoxy-1α,6β,9α-trihydroxylabd-14-en-11-one

 Chemical Name: (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-(Acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1H-naphtho[2,1-b]pyran-1-one; [3R-(3α,4aβ,5β,6β,6aα,10α,10aβ,10bα)]-5-(Acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1H-naphtho[2,1-b]pyran-1-one; 5-(acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-1H-Naphtho[2,1-b]pyran-1-one

Source: From Coleus Forskohlii

Molecular Formula: C22H34O7

Molecular Weight: 410.50

Appearance: Off-white to white powder

Assay(HPLC)≥98%

Biological Activity: Cell-permeable activator of adenylyl cyclase. Hypotensive and vasodilatory agent. Induces neuronal differentiation in stem cells and in several neuroblastoma. Used to reprogram mouse embryonic fibroblasts to induced pluripotent stem cells in combination with three other small molecules. Activates adenylate cyclase leading to an increase in the intracellular concentration of cAMP.

 

 Cyclic AMP (cAMP) is an important signal carrier necessary for the proper biological response of cells to hormones, neurotransmitters, and other extracellular signals. Forskolin is a naturally occurring diterpene that is produced by the Indian Coleus plant (C. forskohlii). It directly activates adenylyl cyclase through its catalytic subunit and is commonly used to raise levels of cAMP in a wide variety of intact cells and tissue preparations. Forskolin binds to adenylyl cyclase in membranes from stably transfected Sf9 cells expressing type 1 adenylyl cyclase with an IC50 value of 41 nM and demonstrates an EC50 value of 0.5 μM in an activation assay assessing formation of cAMP from ATP. Forskolin also interacts with glucose transporters and certain ion channels and has been used for examining adenylyl cyclase expression, regulation, and G protein signaling.

 The major cell-permeable diterpene isolated from the Indian plant Coleus forskohlii. At low doses, it acts as a positive inotropic agent. At higher doses, it serves as a hypotensive and vasodilatory agent due to its actions as a smooth muscle relaxant. No major side effects are observed at effective doses. Forskolins pharmacological activities are due to its activation of adenylate cyclase (EC50 = 4 µM), resulting in increased cAMP levels. The exact mechanism of forskolins positive inotropic effect is unknown but may be related to a cAMP-dependent increase in Na+ permeability that results in indirect augmentation of Ca2+ release. Inhibits MAP kinase in rat renal mesangial cells (IC50 = 25 µM). Also acts as a Hh pathway antagonist. Shown to inhibit apoptosis in cerebellar granule cells and to induce apoptosis in resting human B lymphocytes.

 

 An adenylate cyclase activator and MAP kinase inhibitor. Forskolin is a diterpenoid isolated from Coleus forskohlii, interacts directly with the catalytic subunit of A cyclase (adenylate cyclase), activating the enzyme and raising intracellular levels of cAMP. Forskolin is cell permeable and active in vivo producing positive inotropic, plaet anti-aggregatory and anti-hypertensive effects. Has also been shown to exhibit smooth muscle relaxant activity, decrease in intraocular pressure and the promotion of hormonal release from the pituitary glands. Inhibits MAP kinase, induces phosphorylation of CREB, connexin 43, Bad, ATF-1 and PKB. Forskolin is an inhibitor of AChR.

 Forskolin is a cell permeable diterpenoid isolated from Coleus forskohlii. Cell-permeable diterpenoid that possesses anti-hypertensive, positive inotropic, and adenylyl cyclase activating properties. Many of its biological effects are due to its activation of adenylyl cyclase and the resulting increase in intracellular cAMP concentration.Forskolin effects calcium currents and inhibits MAP kinase.

會員登錄

×

請輸入賬號

請輸入密碼

=

請輸驗證碼

收藏該商鋪

X
該信息已收藏!
標簽:
保存成功

(空格分隔,最多3個,單個標簽最多10個字符)

常用:

提示

X
您的留言已提交成功!我們將在第一時間回復您~
撥打電話
在線留言
人妻媚药乱码一区二区迷| 欧美老熟妇亲子伦高清| 精品妇女一区二区三区| 午夜男女乱淫真视频播放| 久久国产成人一区二区| 亚洲不卡不码黄色大片| 国产精品伦人一久二久三久| 在线一区中文字幕国产| 国内精品偷拍视频久久| 丰满少妇被猛烈进入流水| 欧美日本精品高清视频| 成熟妇女毛耸耸视频做性性色av| 国产日韩欧美综合视频在线| 日韩专区激情综合在线| 97国产大学生情侣在线视频| 精品一线二线三线日本| 精品国产一区二区三区蜜桃| 男人天堂av在线免费观看| 欧美日本桃色视频免费在线看| 欧美成人一区二区免费在线| 成人黄页网站在线观看视频大全| 97午夜福利免费视频| 色播五月亚洲综合图区| 亚洲精品乱码线路中文字幕| 国产精品久久婷婷婷婷| 亚洲最大激情五月婷婷| 日韩精品一区二区av| 中文字幕人妻久久一区| 久久国产乱子伦精品噜噜| 久久久国产精品免费爽爽| 国产亚洲精品久久伦理| 成人女人免费毛片视频| 国产成人精品毛片av| 欧美日韩国产福利精品| 精品欧美一区二区三区久久| 亚洲精品一区二区三区国产| 日本老熟女白胖熟女白| 国产精品一区二区三区四区久久| 国产成人啪精品视频网| 成人福利视频网站视频| 亚洲一区二区欧美日韩|