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愛必信（上海）生物科技有限公司

021-38015121

CHIR-99021 trihydrochloride（2mg）

參考價	￥ 600
訂貨量	≥1

具體成交價以合同協(xié)議為準

￥600

≥1

具體成交價以合同協(xié)議為準

品牌 absin
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廠商性質 生產商
所在地 上海市

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供貨周期	現(xiàn)貨	規(guī)格	2mg
貨號	abs818359

愛必信特色產品線（全部現(xiàn)貨）：二抗、標簽抗體、對照抗體；WB相關：ECL發(fā)光液、預染marker、預制膠；IHC相關：二抗試劑盒、組化筆；IP/CoIP試劑盒；細胞因子、信號通路調節(jié)劑；血清、BSA、蛋白酶K、CTB、TTX、CEE；凋亡試劑盒、呼吸爆發(fā)試劑盒；動植物提取物...

詳細介紹

概述
描述	CHIR-99021 trihydrochloride is a GSK-3α/β inhibitor with IC50 of 10 nM/6.7 nM; > 500-fold selectivity for GSK-3 versus its closest homologs CDC2 and ERK2, as well as other protein kinases.

性能
純度	＞98%
分子量	574.72
化學式	C??H??Cl?N?
分子結構式
溶解性	DMSO: ≥ 32 mg/mL
CAS號	1782235-14-6

參考文獻
[1]. Ring DB et al. Selective glycogen synthase kinase 3 inhibitors potentiate insulin activation of glucose transport and utilization in vitro and in vivo. Diabetes. 2003 Mar;52(3):588-95. [2]. Weikel KA et al. Knockdown of GSK3β increases basal autophagy and AMPK signalling in nutrient-laden human aortic endothelial cells. Biosci Rep. 2016 Sep 16;36(5). [3]. Ai Z et al. CHIR99021 enhances Klf4 Expression through β-Catenin Signaling and miR-7a Regulation in J1 Mouse Embryonic Stem Cells. PLoS One. 2016 Mar 3;11(3) [4]. Preston GC et al. Single cell tuning of Myc expression by antigen receptor signal strength and interleukin-2 in T lymphocytes. EMBO J. 2015 Aug 4;34(15):2008-24. [5]. Preston GC et al. Single cell tuning of Myc expression by antigen receptor signal strength and interleukin-2 in T lymphocytes. EMBO J. 2015 Aug 4;34(15):2008-24.

參考文獻

[1]. Ring DB et al. Selective glycogen synthase kinase 3 inhibitors potentiate insulin activation of glucose transport and utilization in vitro and in vivo. Diabetes. 2003 Mar;52(3):588-95.

[2]. Weikel KA et al. Knockdown of GSK3β increases basal autophagy and AMPK signalling in nutrient-laden human aortic endothelial cells. Biosci Rep. 2016 Sep 16;36(5).

[3]. Ai Z et al. CHIR99021 enhances Klf4 Expression through β-Catenin Signaling and miR-7a Regulation in J1 Mouse Embryonic Stem Cells. PLoS One. 2016 Mar 3;11(3)

[4]. Preston GC et al. Single cell tuning of Myc expression by antigen receptor signal strength and interleukin-2 in T lymphocytes. EMBO J. 2015 Aug 4;34(15):2008-24.

[5]. Preston GC et al. Single cell tuning of Myc expression by antigen receptor signal strength and interleukin-2 in T lymphocytes. EMBO J. 2015 Aug 4;34(15):2008-24.