目錄:普邁精醫(yī)科技（北京）有限公司>>細胞培養(yǎng)產(chǎn)品>>類器官/干細胞培養(yǎng)/細胞培養(yǎng)>> 類器官Prostaglandin E2
| 供貨周期 | 現(xiàn)貨 |
|---|
類器官Prostaglandin E2
類器官（Organoids）是指將成體干細胞或多能干細胞在體外三維培養(yǎng)形成的具有一定空間結構的組織類似物。類器官在組織結構、細胞類型、自我更新能力和功能等方面與來源組織高度一致，從而在發(fā)育生物學、疾病造模、精準醫(yī)學、藥物研發(fā)、基因和細胞療法、感染和免疫以及再生醫(yī)學等生物醫(yī)學的多個領域展現(xiàn)出*的優(yōu)勢。
產(chǎn)品介紹DESCRIPTION
| Background | Prostaglandin E2 is a hormone-like substance that participate in a wide range of body functions such as the contraction and relaxation of smooth muscle, the dilation and constriction of blood vessels, control of blood pressure, and modulation of inflammation. |
| Alias | PGE2；前列腺素 E2；地諾前列酮 |
技術參數(shù)
| M. W t | 352.47 | |
| Formula | C??H??O? | |
| CAS No | 363-24-6 | |
| Storage | Powder | -20°C 3 years |
| In solvent | -80°C 6 months | |
| -20°C 1 month | ||
| Solubility | DMSO | ≥ 100 mg/mL(283.71 mM) |
| Ethanol | 70 mg/mL(198.60 mM) | |
| H2O | < 0.1 mg/mL(insoluble) | |
BIOLOGICAL ALTIVITY
In Vitro
PGE2 shows inhibition of IL 2 production in the mixture of irradiated and nonirradiated T lymphocytes. PGE2 (0.1-10 μM) dose-dependently inhibits the production of IL 2. PGE2 acts during the inductive phase of activation of suppressor cells. Preincubation of T lymphocytes with PGE2 induces cells that suppress IL 2 production and PHA proliferation[1].
In Vivo
PGE2 (0.3 μg/k, i.p.) significantly reduces the number of peritoneab macrophages undergoing phagocytosis of the methacrybate microbeads in rats[2]. PGE2 (0.1 mg/min, i.a.) increases renal blood flow. PGE2 produces a biphasic change in renal vascular resistance, vasodilatation starts at 0.01 mg/min and is maximal at about 3 mg/min, while at the highest dose used (20 mg/min) PGE2 induces renal vasoconstriction[3].
類器官Prostaglandin E2
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