鞘磷脂、腦苷脂以及神經(jīng)節(jié)苷脂系列同位素標記簡介

    鞘脂是一類含有鞘氨醇骨架的兩性脂，是僅次于磷脂的第二大類膜脂。鞘脂一端連接著一個長鏈的脂肪酸，另一端為一個極性的醇。鞘脂正常代謝的維持不僅是細胞生存的關鍵，也對包括抗病免疫調(diào)控、植物育性等在內(nèi)的發(fā)育過程，有著十分重要的作用。絲氨酸棕櫚酰轉(zhuǎn)移酶（Serine palmitoyltransferase, SPT）是催化鞘脂合成的步，同時也是關鍵的限速步驟。在人和酵母中，類黏膜蛋白（Orosomucoid, ORM）通過負調(diào)控SPT酶來維持細胞內(nèi)的鞘脂穩(wěn)態(tài)。穩(wěn)定的同位素標準可以很容易地檢測到質(zhì)譜，同時相比天然鞘脂顯示出幾乎相同的物理性質(zhì),這對于確保分析物和內(nèi)部標準物之間具有相似的提取特性和信號響應非常重要。
    鞘脂包括鞘磷脂、腦苷脂以及神經(jīng)節(jié)苷脂，一般存在于植物和動物膜內(nèi)，尤其是在中樞神經(jīng)系統(tǒng)的組織內(nèi)含量豐富。又稱鞘磷脂、鞘氨醇磷脂或神經(jīng)磷脂·由鞘氨醇、脂肪酸與磷酰膽堿組成的分子，它是鞘磷脂類的典型代表，在高等動物的組織中含量極為豐富。鞘脂作為信號分子在植物生長和脅迫過程中扮演著重要的角色。

     With the availability of stable isotope standards and the incorporation of soft ionization techniques in mass spectrometry the detection of very small amounts of sphingolipids can be accomplished. The two major approaches of sphingolipidomic studies are the liquid chromatography-mass spectrometry based methods and the shotgun lipidomics approach.These techniques require the use of internal standards for each class of sphingolipid expected to be found in a sample. Stable isotope standards can be easily detected by mass spectrometry while demonstrating nearly identical physical properties as compared to natural sphingolipids. This is very important to ensure similar extraction properties and signal response between the analytes and the internal standards.

D-erythro-Sphingosine, D9     1 mg

Synonym:15,15,16,16,17,17,18,18,18-D9-2-Amino-octadec-4-ene-1,3-diol;

N-omega-CD3-Octadecanoyl-D-erythro-sphingosine    1 mg

N-(32-Linoleoyloxy-dotriacontanoyl)-sphingosine-D9  1 mg

N-omega-CD3-Octadecanoyl-D-erythro-dihydrosphingosine  1 mg

N-1-13C-Hexadecanoyl-D-erythro-sphingosylphosphorylcholine   1mg

N-Octadecanoyl-D3-D-erythro-sphingosine-1-phosphate, deuterated   1 mg $

N-Octadecanoyl-D35-psychosine, (perdeuterated, C18:0 fatty acid)   5 mg

N-omega-CD3-Hexadecanoyl-glucopsychosine   1 mg

N-omega-CD3-Octadecanoyl-sulfatide   1 mg

N-omega-CD3-Hexadecanoyl-lactosylceramide   1 mg

N-omega-CD3-Octadecanoyl-ceramide trihexoside   500 µg

N-omega-CD3-Octadecanoyl monosialoganglioside GM1 (NH4+ salt)   500 µg

N-omega-CD3-Octadecanoyl monosialoganglioside GM2 (NH4+ salt)   250 ug

N-omega-CD3-Octadecanoyl monosialoganglioside GM3 (NH4+ salt)  250 ug

N-omega-CD3-Octadecanoyl disialoganglioside GD3   500 µg

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