μ-Conotoxin PIIIA(u-芋螺毒素 PIIIA)  

Blocker of Na_v1.4 channels

鈉離子通道Na_v1.4阻斷劑

μ-Conotoxin PIIIA (mu-conotoxin PIIIA) has been isolated from the venom of the cone Conus purpurascens. μ-conotoxin PIIIA  demonstrates a higher affinity for the mammalian muscle sodium channel  Na_v1.4  (IC₅₀ ~ 44 nM) than for the CNS Na_v1.2 subtype (IC₅₀~ 640 nm). μ-Conotoxin PIIIA  blocks  more  irreversibly amphibian  muscle  sodium  channels  than mammalian ones.

μ-Conotoxin PIIIA(u-芋螺毒素 PIIIA) 技術(shù)資料

氨基酸序列：H-pGlu-Arg-Leu-Cys⁴-Cys⁵-Gly-Phe-Hyp-Lys-Ser-Cys¹¹-Arg-Ser-Arg-Gln-Cys¹⁶-Lys-Hyp-His-Arg-Cys²¹-Cys²²-NH₂ 

二硫鍵：Disulfide bonds between Cys⁴-Cys¹⁶, Cys⁵-Cys²¹ and Cys¹¹-Cys²²

長(zhǎng)度 (aa)：22 

分子式：C₁₀₃H₁₆₅N₄₀O₂₈S₆ 

分子量：2604.10 Da 

外觀： White lyophilized solid 

可溶性：water and saline buffer 

CAS 號(hào)：not available 

來(lái)源： Synthetic  

純度：> 97 %

產(chǎn)品信息