AmmTx3 

Blocker of A-type potassium channels(A型鉀離子通道阻斷劑)

AmmTx3 has been originally isolated from the venom of the scorpion Androctonus mauretanicus and is now offered bySmartox in its synthetic version.  binds on its target A-type potassium channel with an affinity of 66 pM in rat brain synaptosomes (K_v4 channels). As such,  should represent an excellent tool to study action potential firing frequency, spike initiation and waveform in excitable cells.  was indeed found to block A-type potassium currents from cerebellum granular cells and from striatum neurons but with IC₅₀ values of 130 nM.  appears to be a pore blocker of K_v4.2 and K_v4.3 and seems to require the expression of the K_v4 associated protein DPP6. It should also contribute to our understanding of learning, memory and behavior.  shares very high sequence homology with two other A-type potassium channel blockers, Aa1 from Androctonus australis (94%) and BmTx3 from Buthus martensi (91%), and according to binding experiments the same channel target as well.  is a member of the a-KTX 15 family of toxins and consist of a single chain of 37 amino acid residues, with an N-terminal pyroglutamate, cross-linked by three disulfide bridges.

技術(shù)資料

氨基酸序列：

Pyr-Ile-Glu-Thr-Asn-Lys-Lys-Cys⁸-Gln-Gly-Gly-Ser-Cys¹³-Ala-Ser-Val-Cys¹⁷-Arg-Lys-Val-Ile-Gly-Val-Ala-Ala-Gly-Lys-Cys²⁸-Ile-Asn-Gly-Arg-Cys³³-Val-Cys³⁵-Tyr-Pro-OH 

二硫鍵：Cys⁸-Cys²⁸, Cys¹³-Cys³³ and Cys¹⁷-Cys³⁵ 

長(zhǎng)度 (aa)： 37

分子式： C₁₅₈H₂₆₃N₅₁O₄₇S₆  

分子量：3821.52  Da

外觀：white lyophilized solid

可溶性：water or saline buffer

CAS 號(hào)：not available 

來(lái)源：Synthetic

純度：> 98%

產(chǎn)品信息