Conantokin-G（芋螺抑制肽G）  

Selective inhibitor of NR2B-containing NMDAR

NMDAR（N-甲基-D-天冬氨酸受體）亞單位NR2B的選擇性抑制劑

Conantokin-G has been isolated from the venom of the cone Conus geographus. Conantokin-Gselectively inhibits NR2B containing N-methyl-D-aspartate receptors (NMDAR) with a high specificity. Thus, Conantokin-G inhibits in a concentration-dependent manner the Ca²⁺ influx leading to a neuroprotective effect against NMDA-induced excitotoxicity. Conantokin-G was shown to block NMDA-evoked currents in murine cortical neurons with an IC₅₀ value of around 480 nM.

Conantokin-G 技術(shù)資料

氨基酸序列： Gly-Glu-Gla-Gla-Leu-Gln-Gla-Asn-Gln-Gla-Leu-Ile-Arg-Gla-Lys-Ser-Asn-NH₂ 

長(zhǎng)度 (aa)：17

分子式： C₈₈H₁₃₈N₂₆O₄₄ 

分子量： 2264.23 Da

外觀： White lyophilized solid

可溶性：water and saline buffer

CAS 號(hào)： [93438-65-4]

來(lái)源： Synthetic 

純度：> 94.5 %

產(chǎn)品信息