GaTx1 

Selective blocker of CFTR channels(CFTR通道選擇性阻斷劑)

The GaTx1 peptide was originally isolated from the venom of Leiurus quinquestriatus hebraeus.  is a potent and selective inhibitor of CFTR, an anion selective channel belonging to the ABC transporter superfamily. It was shown to block CFTR channels in a state dependent manner by acting from the internal face of the channel and it is supposed to be a non competitive inhibitor of ATP-dependent channel gating.  is a valuable tool to explore the function of CFTR. 
 

技術(shù)資料

氨基酸序列：

 Cys¹-Gly-Pro-Cys⁴-Phe-Thr-Thr-Asp-His-Gln-Met-Glu-Gln-Lys-Cys¹⁵-Ala-Glu-Cys¹⁸-Cys¹⁹-Gly-Gly-Ile-Gly-Lys-Cys²⁵-Tyr-Gly-Pro-Gln-Cys³⁰-Leu-Cys³²-Asn-Arg-NH₂ 

二硫鍵： Cys¹-Cys¹⁸, Cys⁴-Cys²⁵, Cys¹⁵-Cys³⁰, and Cys¹⁹-Cys³² 

長度 (aa)：34

分子式： C₁₄₇H₂₂₄N₄₆O₄₇S₉₆   

分子量： 3674.2 Da

外觀：White lyophilized solid

可溶性： water and saline buffer

CAS 號： not available

來源：Synthetic 

純度： > 98 %

產(chǎn)品信息