Apamin 

Inhibitor of small conductance Ca²⁺-activated K⁺ channels

小電導鈣激活鉀離子通道抑制劑

Apamin is a neurotoxin that was originally isolated from Apis mellifera. Apamin binds to and inhibits the  SK channels(small conductance Ca²⁺-activated K⁺ channels) in the brain and spinal cord. Apamin inhibits three subtypes of SK channels (K_Ca2.1, K_Ca2.2, and K_Ca2.3) with different affinity. Apamin does not affect K_Ca3.1 channel activity. Apaminmost likely acts as a pore blocker such as Scyllatoxin or Tamapin, although residues both inside and outside of the pore region of the SK channels participate in apamin binding. The SK channels are present in a wide range of excitable and non-excitable cells, including cells in the central nervous system, intestinal myocytes, endothelial cells, and hepatocytes.

Apamin 技術(shù)資料

氨基酸序列：

 H-Cys¹-Asn-Cys³-Lys-Ala-Pro-Glu-Thr-Ala-Leu-Cys¹¹-Ala-Arg-Arg-Cys¹⁵-Gln-Gln-His-NH₂ 

二硫鍵：Cys¹-Cys¹¹ and Cys³-Cys¹⁵ 

長度 (aa)： 18

分子式： C₇₉H₁₃₁N₃₁O₂₄S₄ 

分子量：2027.34 Da

外觀： White lyophilized solid

可溶性：water and saline buffer

CAS 號： [24345-16-2]

來源： Synthetic 

純度： > 98 %

產(chǎn)品信息