08HWT002Huwentoxin-IV(虎紋捕鳥蛛神經(jīng)毒素-IV)
【簡單介紹】
品牌 | Smartox |
---|
【詳細說明】
Huwentoxin-IV(虎紋捕鳥蛛神經(jīng)毒素-IV)
TTX-S selective blocker(電壓門控鈉離子通道TTX-S選擇性阻斷劑)
Huwentoxin IV (HwTx-IV) is a neurotoxin that was originally isolated from Haplopelma schmidti (Chinese bird spider). This lethal neurotoxin acts selectively on tetrodotoxin-sensitive (TTX-S) voltage-gated sodium channels, with an IC50 of 30 nM in rat DRG neurons. It preferentially inhibits neuronal voltage-gated sodium channel subtype hNav1.7 (SCN9A, IC50 is 26 nM), rNav1.2 (SCN2A, IC50 is 150 nM), and rNav1.3 (SCN3A, IC50 is 338 nM), compared with muscle subtypes rNav1.4 (SCN4A) and hNav1.5 (SCN5A) (IC50 is > 10 µM).Huwentoxin IV inhibits the activation of sodium channels by trapping the voltage sensor of domain II of the site 4 in the inward, closed configuration.
Huwentoxin-IV(虎紋捕鳥蛛神經(jīng)毒素-IV)技術(shù)資料
氨基酸序列:
Glu-Cys2-Leu-Glu-Ile-Phe-Lys-Ala-Cys9-Asn-Pro-Ser-Asn-Asp-Gln-Cys16-Cys17-Lys-Ser-Ser-Lys-Leu-Val-Cys24-Ser-Arg-Lys-Thr-Arg-Trp-Cys31-Lys-Tyr-Gln-Ile-NH2
二硫鍵:Cys2-Cys17, Cys9-Cys24 and Cys16-Cys31
長度 (aa):35
分子式:C174H277N51O52S6
分子量:4109.18 Da
外觀:White lyophilized solid
可溶性: water and saline buffer
CAS 號:not available
來源:Synthetic
純度:> 97 %
產(chǎn)品信息
08HWT002-00100 | Huwentoxin IV | 0.1mg |
08HWT002-00500 | Huwentoxin IV | 0.5mg |
08HWT002-01000 | Huwentoxin IV | 1mg |
相關(guān)產(chǎn)品
- 08CON013ω-Conotoxin-SO3 (ω-漏斗網(wǎng)蛛毒素SO3 )
- 08CON002ω-Conotoxin MVIIC / Omega conotoxin MVIIC (ω-漏斗網(wǎng)蛛毒
- 08CON001ω-Conotoxin MVIIA (ω-漏斗網(wǎng)蛛毒素MVIIA)
- 08CON003ω-conotoxin GVIA(ω-漏斗網(wǎng)蛛毒素GVIA)
- 11AGA001ω-agatoxin IVA(ω-漏斗網(wǎng)蛛毒素 IVA)
- 12JZH003Jingzhaotoxin III(JZTx-III,敬釗纓毛蛛毒素-III)
- 08HWT002Huwentoxin-IV(虎紋捕鳥蛛神經(jīng)毒素-IV)
- 07HWT001Huwentoxin-I(虎紋捕鳥蛛神經(jīng)毒素-I)
- 12HTX001Hainantoxin-IV(海南捕鳥蛛毒素-IV)
- 13HTX003Hainantoxin-III(海南捕鳥蛛毒素-Ⅲ)
請輸入產(chǎn)品關(guān)鍵字:
郵編:100083
聯(lián)系人:尤女士
電話:4008858216
傳真:
手機:13581534696
留言:發(fā)送留言
個性化:www.qbiotec.com
網(wǎng)址:www.qbiotec.com
商鋪:http://www.hbwxwy.cn/st289923/