ω-Conotoxin-SO3 (ω-漏斗網(wǎng)蛛毒素SO3 ) 

Selective blocker of N-type calcium channels

N型鈣通道選擇性阻斷劑

ω-conotoxin SO-3 is a selective blocker of N-type voltage-sensitive calcium channels. EC₅₀ for ω-conotoxin SO-3 is 0.16 µM (similar to ω-conotoxin MVIIA) on HVA calcium currents. ω-conotoxin SO-3 did not show any inhibiting effects on L-type, P/Q-type and R-type currents at 3 µM concentration. ω-conotoxin SO-3 has no effect on voltage-sensitive sodium currents, delayed rectifier potassium currents and transient outward potassium currents. At 3 µM, the inhibition amounts of HVA I_Ca was very similar between ω-conotoxin SO-3 and ω-conotoxin MVIIA (~ 32%). Their inhibitory effects are almost fully reversible but their half-time for recovery are different (~ 7.5 min for ω-conotoxin SO-3 and  ~ 4.14 min for ω-conotoxin MVIIA). ω-conotoxin SO-3 displays an analgesic potency similar to ω-conotoxin MVIIA in a range of acute and chronic pain models in rodents, but has less adverse effects compared with identical dosages of ω-conotoxin MVIIA injected intrathecally.

ω-Conotoxin-SO3 (ω-漏斗網(wǎng)蛛毒素SO3 )技術(shù)資料

氨基酸序列：

Cys¹-Lys-Ala-Ala-Gly-Lys-Pro-Cys⁸-Ser-Arg-Ile-Ala-Tyr-Asn-Cys¹⁵-Cys¹⁶-Thr-Gly-Ser-Cys²⁰-Arg-Ser-Gly-Lys-Cys²⁵-NH₂ 

二硫鍵：Cys¹-Cys¹⁶, Cys⁸-Cys²⁰ and Cys¹⁵-Cys²⁵ 

長度 (aa)：25

分子式： C₁₀₀H₁₆₅N₃₅O₃₂S₆ 

分子量： 2567.07 Da

外觀：White lyophilized solid

可溶性： water and saline buffer

CAS 號(hào)：not available 

來源：Synthetic

純度：> 97 %

產(chǎn)品信息